The Nitroalkene (E)-8-nitrononadec-7-enoic Acid (CP-8) is a Reversible Covalent Inhibitor of DNA -DSB Repair and Activator of Adaptive PD-L1 Signaling in Ovarian Cancer

IF 8 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Free Radical Biology and Medicine Pub Date : 2026-09-01 Epub Date: 2026-09-23 DOI:10.1016/j.freeradbiomed.2026.08.075

Priscilla Tang, Lisa Hong, Sarah Alsaad, Sierra White, Dennis Braden, John Skoko, Nadine Hempel, Lan Coffman, Francisco Schopfer, Carola Neumann

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硝基烯(E)-8-硝基膦酸-7-烯酸（CP-8）是卵巢癌DNA -DSB修复的可逆共价抑制剂和适应性PD-L1信号通路的激活剂

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来源期刊

Free Radical Biology and Medicine 医学-内分泌学与代谢

CiteScore

14.00

自引率

4.10%

发文量

850

审稿时长

22 days

期刊介绍： Free Radical Biology and Medicine is a leading journal in the field of redox biology, which is the study of the role of reactive oxygen species (ROS) and other oxidizing agents in biological systems. The journal serves as a premier forum for publishing innovative and groundbreaking research that explores the redox biology of health and disease, covering a wide range of topics and disciplines. Free Radical Biology and Medicine also commissions Special Issues that highlight recent advances in both basic and clinical research, with a particular emphasis on the mechanisms underlying altered metabolism and redox signaling. These Special Issues aim to provide a focused platform for the latest research in the field, fostering collaboration and knowledge exchange among researchers and clinicians.