Justin H M Yung, Emily G Hoffman, Aleksandar Ivovic, S M Niazur Rahman, Tejas Desai, Khajag Koulajian, Yusaku Mori, Charles Maisonneuve, Marry Nissan, Ayse Bengisu Gelmez, Yasmin Rabiee, Sandra Pereira, Dana Al-Rijjal, Michael B Wheeler, Dana J Philpott, Adria Giacca, Kacey J Prentice
{"title":"Nod1 Plays a Causal Role in Palmitate-Induced β-Cell Dysfunction In Vitro and In Vivo in Male Mice.","authors":"Justin H M Yung, Emily G Hoffman, Aleksandar Ivovic, S M Niazur Rahman, Tejas Desai, Khajag Koulajian, Yusaku Mori, Charles Maisonneuve, Marry Nissan, Ayse Bengisu Gelmez, Yasmin Rabiee, Sandra Pereira, Dana Al-Rijjal, Michael B Wheeler, Dana J Philpott, Adria Giacca, Kacey J Prentice","doi":"10.2337/db25-0752","DOIUrl":null,"url":null,"abstract":"<p><strong>Article highlights: </strong>The innate immunity receptor nucleotide-binding oligomerization domain 1 (Nod1) can be activated by saturated fatty acids and is implicated in high-fat diet-induced inflammation and insulin resistance. This implies Nod1 plays a role in glucose homeostasis; therefore, we sought to determine whether saturated fatty acids cause pancreatic β-cell dysfunction through Nod1. Our data demonstrate that Nod1 is involved in palmitate-induced β-cell dysfunction in vitro and in vivo.</p>","PeriodicalId":93977,"journal":{"name":"Diabetes","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2337/db25-0752","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Article highlights: The innate immunity receptor nucleotide-binding oligomerization domain 1 (Nod1) can be activated by saturated fatty acids and is implicated in high-fat diet-induced inflammation and insulin resistance. This implies Nod1 plays a role in glucose homeostasis; therefore, we sought to determine whether saturated fatty acids cause pancreatic β-cell dysfunction through Nod1. Our data demonstrate that Nod1 is involved in palmitate-induced β-cell dysfunction in vitro and in vivo.
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