Timed Up-and-Go Test Using Instrumented Insoles to Monitor Tibial or Malleolar Fracture Healing in Patients With Healing Fractures or Nonunion: Longitudinal and Cross-Sectional Exploratory Study.

Abstract

Background: The timed up-and-go (TUG) test is a mobility-related functional task commonly performed in clinical practice for a variety of clinical applications. By instrumenting the TUG test with sensors, creating an instrumented TUG (iTUG), additional parameters can be extracted, which may add clinical value. Instrumented insoles are among the most promising wearable devices that are currently being explored for clinical purposes.

Objective: The study aims to assess additional parameters obtained by instrumenting the TUG test with pressure-sensing insoles for monitoring fracture healing and to analyze whether these parameters reveal differences between patients with and without union of tibial or malleolar fractures.

Methods: Patients with tibial or malleolar fractures and matched controls were enrolled. Patients' TUG test data were collected as follows: (1) longitudinally-at 6 weeks, 3 months, and 6 months after surgery-and (2) cross-sectionally-at 6 months after surgery when patients were referred for nonunion treatment. All participants performed the TUG test using instrumented insoles. TUG tests were video-recorded and analyzed in terms of the time taken to complete each part of the TUG test (conventional TUG). The insole data-derived outcome measures were maximal force during sit-to-stand and stand-to-sit movements, stance time and stride time during walking, and asymmetry of the previously mentioned parameters (iTUG).

Results: Twenty-seven patients with fracture, a similar number of healthy adults, and 9 patients with fracture nonunion were assessed. All TUG parameters improved throughout the healing process (all P<.001). The greatest improvements were detected between 6 weeks and 3 months (all P<.001). Among the classical TUG parameters, between 3 and 6 months, only the total TUG time, walking time, stand-to-sit time, and total number of steps significantly improved (P=.004, P=.01, P=.03, and P=.002). Based on the additional iTUG measures, 6 months after surgery, the loading of the injured side was reduced in patients compared with healthy controls during sit-to-stand and stand-to-sit movements (P<.001). Six months after surgery, patients with fracture nonunion had significantly poorer performance in terms of all of the TUG test parameters, except for stance time, than patients with fracture union.

Conclusions: This study indicates the potential for using functional outcomes to identify patients at risk of nonunion. Additional tasks and functional outcomes require further investigation.