Therapeutic effects of Zataria multiflora Boiss. extract-loaded chitosan nanoparticles against asthma in rats.

IF 3 Q3 CHEMISTRY, MEDICINAL

Avicenna Journal of Phytomedicine Pub Date : 2026-01-01 DOI:10.22038/ajp.2025.26641

Najmeh Parvaz, Mahboubeh Mirhosseini, Saeideh Saadat, Fatemeh Amin, Leila Etemad

{"title":"Therapeutic effects of Zataria multiflora Boiss. extract-loaded chitosan nanoparticles against asthma in rats.","authors":"Najmeh Parvaz, Mahboubeh Mirhosseini, Saeideh Saadat, Fatemeh Amin, Leila Etemad","doi":"10.22038/ajp.2025.26641","DOIUrl":null,"url":null,"abstract":"Objective: Asthma is one of the most common chronic inflammatory disorders worldwide. Zataria multiflora Boiss., widely used in herbal medicine, shows potential efficacy against asthma. In this study, Z. multiflora was encapsulated in chitosan nanoparticles to improve its therapeutic effectiveness against asthma in rats.Materials and methods: Thirty-six rats were divided to 6 groups including control, asthma (sensitized to ovalbumin (OVA)), and asthmatic groups treated with dexamethasone, empty nano-chitosan, and 8 and 80 mg/kg nano Z. multiflora hydroalcoholic extract (Herbarium No: 35314, FUMH) through inhalation. Superoxide dismutase (SOD) and catalase (CAT) activities, malondialdehyde (MDA) concentration, total white blood cells (WBC) counts, interferon-gamma (IFN-γ), interleukin-4 (IL-4) and IFN-γ to IL-4 ratio in bronchoalveolar lavage fluid (BALF) and tracheal responsiveness were assessed.Results: Nano Z. multiflora treatment significantly reduced WBC count and levels of MDA and IL-4 compared to the asthma group. Also, the nano extract of Z. multiflora caused a protective effect on elevated tracheal responsiveness to methacholine and ovalbumin.Conclusion: The therapeutic efficacy of Z. multiflora can potentially be enhanced through targeted delivery using chitosan nanoparticles administered via inhalation in asthmatic rats.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"16 5","pages":"798-810"},"PeriodicalIF":3.0000,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13592763/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Avicenna Journal of Phytomedicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22038/ajp.2025.26641","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: Asthma is one of the most common chronic inflammatory disorders worldwide. Zataria multiflora Boiss., widely used in herbal medicine, shows potential efficacy against asthma. In this study, Z. multiflora was encapsulated in chitosan nanoparticles to improve its therapeutic effectiveness against asthma in rats.

Materials and methods: Thirty-six rats were divided to 6 groups including control, asthma (sensitized to ovalbumin (OVA)), and asthmatic groups treated with dexamethasone, empty nano-chitosan, and 8 and 80 mg/kg nano Z. multiflora hydroalcoholic extract (Herbarium No: 35314, FUMH) through inhalation. Superoxide dismutase (SOD) and catalase (CAT) activities, malondialdehyde (MDA) concentration, total white blood cells (WBC) counts, interferon-gamma (IFN-γ), interleukin-4 (IL-4) and IFN-γ to IL-4 ratio in bronchoalveolar lavage fluid (BALF) and tracheal responsiveness were assessed.

Results: Nano Z. multiflora treatment significantly reduced WBC count and levels of MDA and IL-4 compared to the asthma group. Also, the nano extract of Z. multiflora caused a protective effect on elevated tracheal responsiveness to methacholine and ovalbumin.

Conclusion: The therapeutic efficacy of Z. multiflora can potentially be enhanced through targeted delivery using chitosan nanoparticles administered via inhalation in asthmatic rats.

查看原文本刊更多论文

何首乌的治疗效果。壳聚糖纳米颗粒提取物对大鼠哮喘的作用。

目的：哮喘是世界上最常见的慢性炎症性疾病之一。多花扎莉。在草药中广泛使用，显示出对哮喘的潜在疗效。本研究采用壳聚糖纳米粒包封多花草，以提高其对哮喘大鼠的治疗效果。材料与方法：将36只大鼠分为对照组、哮喘组（卵清蛋白致敏组）和哮喘组（地塞米松、空纳米壳聚糖、8和80 mg/kg纳米多花水醇提取物（标本室编号：35314，FUMH）吸入组）。测定支气管肺泡灌洗液（BALF）中超氧化物歧化酶（SOD）、过氧化氢酶（CAT）活性、丙二醛（MDA）浓度、白细胞总数（WBC）、干扰素-γ (IFN-γ)、白细胞介素-4 （IL-4）、IFN-γ / IL-4比值及气管反应性。结果：与哮喘组相比，纳米z治疗显著降低WBC计数和MDA、IL-4水平。多花莲纳米提取物对气管对乙酰胆碱和卵清蛋白的反应有保护作用。结论：壳聚糖纳米颗粒经吸入给药可提高多连草对哮喘大鼠的治疗作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊