Nonsteroidal Anti-Inflammatory Drug Mefenamic Acid Induces Dysbiosis by Depleting Butyrogenic Gut Commensals

IF 4.1 3区医学 Q2 CHEMISTRY, MEDICINAL

Chemical Research in Toxicology Pub Date : 2026-09-21 Epub Date: 2026-08-31 DOI:10.1021/acs.chemrestox.6c00394

Nehal Batra, Prangya Ranjan Rout, Priyankar Dey

引用次数: 0

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) possess severe side effects, including various types of gastrointestinal symptoms. Mefenamic acid is one of the most widely used NSAIDs globally. Using an anaerobic in vitro fermentation model, we showed that mefenamic acid reduced the abundance of gut commensals and increased the abundance of pathobionts. Specifically, butyrate-producing commensals were reduced with mefenamic acid treatment. These results corroborate the metabolomics data showing depletion of butyrate, propionate, and their derivatives. Therefore, NSAID consumption could lead to gut dysbiosis, which in turn could lead to gastrointestinal complications generally associated with long-term NSAID use.

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非甾体抗炎药甲氧胺酸通过消耗肠道共生菌诱导生态失调

非甾体抗炎药（NSAIDs）具有严重的副作用，包括各种胃肠道症状。甲非那酸是全球使用最广泛的非甾体抗炎药之一。通过体外厌氧发酵模型，我们发现甲氨酸降低了肠道共生菌的丰度，增加了病原体的丰度。具体来说，产丁酸共生体在甲胺酸处理下减少。这些结果证实了代谢组学数据显示丁酸盐、丙酸盐及其衍生物的消耗。因此，服用非甾体抗炎药可能导致肠道生态失调，这反过来又可能导致胃肠道并发症，通常与长期使用非甾体抗炎药有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical Research in Toxicology 医学-毒理学

CiteScore

7.90

自引率

7.30%

发文量

215

审稿时长

3.5 months

期刊介绍： Chemical Research in Toxicology publishes Articles, Rapid Reports, Chemical Profiles, Reviews, Perspectives, Letters to the Editor, and ToxWatch on a wide range of topics in Toxicology that inform a chemical and molecular understanding and capacity to predict biological outcomes on the basis of structures and processes. The overarching goal of activities reported in the Journal are to provide knowledge and innovative approaches needed to promote intelligent solutions for human safety and ecosystem preservation. The journal emphasizes insight concerning mechanisms of toxicity over phenomenological observations. It upholds rigorous chemical, physical and mathematical standards for characterization and application of modern techniques.