Electrochemical deaminative thiocyanation of aromatic amines

IF 4.5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2026-09-22 DOI:10.1039/d6qo01128d

Yong Liu,Jijin Li,Yuelong He,Lin-Bao Zhang,Weisi Guo

引用次数: 0

Abstract

Deaminative functionalization of aromatic amines through diazotization represents an important strategy for constructing diverse aromatic compounds. Herein, we report an electrochemical protocol for the direct deaminative thiocyanation of aromatic amines via aryl diazonium salts as transient intermediates. TMSNCS serves as a reductant to reduce readily available nitrate, generating NO₂ intermediates. Electrochemical oxidation enables the regeneration of FeIII from FeII. This method features a broad substrate scope, easy scalability and can be applied for late-stage functionalization of bioactive molecules.

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芳香胺的电化学脱氨硫氰化

芳香族胺重氮化脱胺功能化是构建多样化芳香族化合物的重要策略。在此，我们报告了一种通过芳基重氮盐作为瞬态中间体直接脱氨硫氰化芳胺的电化学方案。TMSNCS作为还原剂可还原易获得的硝酸盐，生成NO₂中间体。电化学氧化使FeII再生为FeIII。该方法具有底物范围广，易于扩展，可用于生物活性分子的后期功能化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.