Commentary on Canadian study on timing of methadone take-homes

Alison Knopf
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Abstract

A study published in JAMA Internal Medicine found that initiating take-home dosing of methadone after treatment induction was associated with a reduction in treatment dropouts, as well as a reduction in deaths, compared to no take-homes. The study, “Timing of Initiation of Methadone Take-Home Dosing,” authored by Belal Hossain, M.D., and colleagues, controlled for confounding factors. Completion of induction was defined as two weeks with no change in daily dose, which translated to about four weeks after methadone induction for most patients.

加拿大关于美沙酮服用时间的研究述评
发表在《美国医学会内科杂志》(JAMA Internal Medicine)上的一项研究发现,与不带回家治疗相比,在治疗诱导后开始带回家服用美沙酮与减少治疗退出和减少死亡有关。这项名为“美沙酮带回家给药的起始时间”的研究由医学博士Belal Hossain和他的同事撰写,控制了混杂因素。诱导完成的定义是两周内每日剂量没有变化,这对大多数患者来说转化为美沙酮诱导后约四周。
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