Zhipeng Yin, Zichong Wang, Min Chen, Ian Stockwell, Xin Ning, Jun Liu, Wenbin Zhang
{"title":"Assisting patients with reliable information gathering: A guide to building efficient QA systems for medical use.","authors":"Zhipeng Yin, Zichong Wang, Min Chen, Ian Stockwell, Xin Ning, Jun Liu, Wenbin Zhang","doi":"10.1371/journal.pdig.0001634","DOIUrl":null,"url":null,"abstract":"<p><p>The application of question-answering (QA) systems in the medical domain has rapidly advanced, significantly improving patients' access to reliable health-related information. However, current approaches face notable challenges, including the difficulty in obtaining large-scale and unbiased medical datasets, significant privacy concerns, and inefficiencies due to manual dataset annotation. To address these issues, This study introduce a novel methodology leveraging publicly accessible online health forums to systematically build an unbiased, privacy-conscious QA dataset, and it employs Topic-guided Semantic Modeling (TGSM) for automated topic identification, enabling efficient and targeted annotation of relevant patient-generated content. Subsequently, this study propose a two-stage QA pipeline based on a Retriever-Reader architecture, which is further enhanced through fine-tuning state-of-the-art transformer-based models on the constructed domain-specific QA dataset. Experimental results demonstrate that our fine-tuned BioBERT significantly outperforms existing benchmarks, offering accurate patient-derived insights and providing a replicable framework for building efficient medical QA systems.</p>","PeriodicalId":74465,"journal":{"name":"PLOS digital health","volume":"5 9","pages":"e0001634"},"PeriodicalIF":7.7000,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13585261/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"PLOS digital health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1371/journal.pdig.0001634","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/9/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The application of question-answering (QA) systems in the medical domain has rapidly advanced, significantly improving patients' access to reliable health-related information. However, current approaches face notable challenges, including the difficulty in obtaining large-scale and unbiased medical datasets, significant privacy concerns, and inefficiencies due to manual dataset annotation. To address these issues, This study introduce a novel methodology leveraging publicly accessible online health forums to systematically build an unbiased, privacy-conscious QA dataset, and it employs Topic-guided Semantic Modeling (TGSM) for automated topic identification, enabling efficient and targeted annotation of relevant patient-generated content. Subsequently, this study propose a two-stage QA pipeline based on a Retriever-Reader architecture, which is further enhanced through fine-tuning state-of-the-art transformer-based models on the constructed domain-specific QA dataset. Experimental results demonstrate that our fine-tuned BioBERT significantly outperforms existing benchmarks, offering accurate patient-derived insights and providing a replicable framework for building efficient medical QA systems.