The chick embryo chorioallantoic membrane as an in vivo assay to study the skin in melanoma and other skin pathological conditions.

IF 4.1 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

Internal and Emergency Medicine Pub Date : 2026-09-17 DOI:10.1007/s11739-026-04525-5

Domenico Ribatti, Roberto Tamma

引用次数: 0

Abstract

The chick chorioallantoic membrane (CAM) is a well-established model for studying angiogenesis, tumor growth, tissue grafting, and therapeutic responses; however, conventional in ovo approaches are limited by a short experimental window, immune-related constraints, and restricted imaging accessibility. Being naturally immunodeficient, the chick embryo accepts transplantation from various tissues and species. This article analyzes the literature data concerning the use of the CAM model to study melanoma and other skin pathological conditions, due to the lack of literature data summarizing this topic.

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以鸡胚绒毛尿囊膜为实验材料，研究其皮肤在黑色素瘤等皮肤病理状况下的作用。

鸡毛囊尿囊膜（CAM）是研究血管生成、肿瘤生长、组织移植和治疗反应的良好模型；然而，传统的卵内入路受到实验窗口短、免疫相关限制和成像可及性的限制。由于天生免疫缺陷，鸡胚可以接受各种组织和物种的移植。由于缺乏总结该主题的文献数据，本文分析了有关使用CAM模型研究黑色素瘤等皮肤病理状况的文献数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Internal and Emergency Medicine 医学-医学：内科

CiteScore

7.20

自引率

4.30%

发文量

258

审稿时长

6-12 weeks

期刊介绍： Internal and Emergency Medicine (IEM) is an independent, international, English-language, peer-reviewed journal designed for internists and emergency physicians. IEM publishes a variety of manuscript types including Original investigations, Review articles, Letters to the Editor, Editorials and Commentaries. Occasionally IEM accepts unsolicited Reviews, Commentaries or Editorials. The journal is divided into three sections, i.e., Internal Medicine, Emergency Medicine and Clinical Evidence and Health Technology Assessment, with three separate editorial boards. In the Internal Medicine section, invited Case records and Physical examinations, devoted to underlining the role of a clinical approach in selected clinical cases, are also published. The Emergency Medicine section will include a Morbidity and Mortality Report and an Airway Forum concerning the management of difficult airway problems. As far as Critical Care is becoming an integral part of Emergency Medicine, a new sub-section will report the literature that concerns the interface not only for the care of the critical patient in the Emergency Department, but also in the Intensive Care Unit. Finally, in the Clinical Evidence and Health Technology Assessment section brief discussions of topics of evidence-based medicine (Cochrane’s corner) and Research updates are published. IEM encourages letters of rebuttal and criticism of published articles. Topics of interest include all subjects that relate to the science and practice of Internal and Emergency Medicine.