How a Rare Inherited Lung Cancer Mutation Took Root in Appalachia

IF 29.5 1区医学 Q1 ONCOLOGY

Cancer discovery Pub Date : 2026-09-17 DOI:10.1158/2159-8290.cd-nw2026-0089

引用次数: 0

Abstract

A rare inherited EGFR mutation took root in Southern Appalachia after being carried to the United States by European settlers in the 1700s. Mapping the distribution of this germline EGFRT790M variant could help clinicians identify people at elevated risk of lung cancer and target them for genetic testing and closer surveillance.

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一种罕见的遗传性肺癌突变是如何在阿巴拉契亚扎根的

一种罕见的遗传EGFR突变在18世纪被欧洲定居者带到美国后，在阿巴拉契亚南部生根发芽。绘制这种种系EGFRT790M变异的分布可以帮助临床医生识别肺癌风险升高的人群，并针对他们进行基因检测和更密切的监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer discovery ONCOLOGY-

CiteScore

22.90

自引率

1.40%

发文量

838

审稿时长

6-12 weeks

期刊介绍： Cancer Discovery publishes high-impact, peer-reviewed articles detailing significant advances in both research and clinical trials. Serving as a premier cancer information resource, the journal also features Review Articles, Perspectives, Commentaries, News stories, and Research Watch summaries to keep readers abreast of the latest findings in the field. Covering a wide range of topics, from laboratory research to clinical trials and epidemiologic studies, Cancer Discovery spans the entire spectrum of cancer research and medicine.