Trends in the Proportion of Hepatitis C Virus Antibody-Positive Patients Who Could be Considered for Direct-Acting Antiviral Therapy Identified Through Preoperative Testing for Ophthalmic Surgery: A Nationwide Multicenter Real-World Cohort Study in Japan.

IF 3.7 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Hepatology Research Pub Date : 2026-09-16 DOI:10.1111/hepr.70271

Ritsuzo Kozuka, Yoshihito Uchida, Hatsue Fujino, Akira Asai, Tatsuya Ide, Masaru Enomoto, Hiroki Tojima, Hirokazu Takahashi, Jun Inoue, Tadashi Ikegami, Yoshio Tokumoto, Mizuki Endo, Mika Horino, Ryo Sasaki, Tetsuro Shimakami, Koji Sawada, Kazuhito Kawata, Masatsugu Ohara, Kenji Nagata, Takako Inoue, Satoru Kakizaki, Masaaki Korenaga

{"title":"Trends in the Proportion of Hepatitis C Virus Antibody-Positive Patients Who Could be Considered for Direct-Acting Antiviral Therapy Identified Through Preoperative Testing for Ophthalmic Surgery: A Nationwide Multicenter Real-World Cohort Study in Japan.","authors":"Ritsuzo Kozuka, Yoshihito Uchida, Hatsue Fujino, Akira Asai, Tatsuya Ide, Masaru Enomoto, Hiroki Tojima, Hirokazu Takahashi, Jun Inoue, Tadashi Ikegami, Yoshio Tokumoto, Mizuki Endo, Mika Horino, Ryo Sasaki, Tetsuro Shimakami, Koji Sawada, Kazuhito Kawata, Masatsugu Ohara, Kenji Nagata, Takako Inoue, Satoru Kakizaki, Masaaki Korenaga","doi":"10.1111/hepr.70271","DOIUrl":null,"url":null,"abstract":"Background and aims: Although the widespread use of direct-acting antivirals (DAAs) has reduced the proportion of hepatitis C virus (HCV) antibody-positive patients eligible for antiviral treatment, the current proportion requiring referral for DAA therapy in ophthalmology departments, which have both high testing volumes and high HCV antibody-positive rates, remains unclear.Methods: This nationwide multicenter retrospective cohort study included HCV antibody-positive patients identified through testing in ophthalmology departments at 20 institutions in Japan between 2019 and 2023. The proportions of patients requiring referral for DAA therapy were assessed by electronic medical record (EMR) review across all 20 institutions and by a combination of EMR review and HCV antibody titer determination across nine institutions where antibody titers could be measured.Results: A total of 2792 HCV antibody-positive patients were identified across 20 institutions. Based on EMR review, the proportions requiring referral for DAA therapy were 44.4%, 38.7%, 34.2%, 38.9%, and 42.5% in 2019, 2020, 2021, 2022, and 2023, respectively. Among 1255 HCV antibody-positive patients from 9 institutions where HCV antibody titers could be determined, the corresponding proportions assessed by combined EMR review and antibody titer determination were 28.4%, 23.7%, 20.8%, 22.4%, and 25.9%, respectively. Despite a decline in HCV antibody-positive rates over time, the proportion requiring referral remained high.Conclusions: Although the number of HCV antibody-positive patients in ophthalmology departments has decreased, a considerable proportion could still be considered for DAA therapy. Combining HCV antibody titer determination with EMR review improves the efficiency of identifying patients requiring referral.","PeriodicalId":12987,"journal":{"name":"Hepatology Research","volume":" ","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hepatology Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/hepr.70271","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background and aims: Although the widespread use of direct-acting antivirals (DAAs) has reduced the proportion of hepatitis C virus (HCV) antibody-positive patients eligible for antiviral treatment, the current proportion requiring referral for DAA therapy in ophthalmology departments, which have both high testing volumes and high HCV antibody-positive rates, remains unclear.

Methods: This nationwide multicenter retrospective cohort study included HCV antibody-positive patients identified through testing in ophthalmology departments at 20 institutions in Japan between 2019 and 2023. The proportions of patients requiring referral for DAA therapy were assessed by electronic medical record (EMR) review across all 20 institutions and by a combination of EMR review and HCV antibody titer determination across nine institutions where antibody titers could be measured.

Results: A total of 2792 HCV antibody-positive patients were identified across 20 institutions. Based on EMR review, the proportions requiring referral for DAA therapy were 44.4%, 38.7%, 34.2%, 38.9%, and 42.5% in 2019, 2020, 2021, 2022, and 2023, respectively. Among 1255 HCV antibody-positive patients from 9 institutions where HCV antibody titers could be determined, the corresponding proportions assessed by combined EMR review and antibody titer determination were 28.4%, 23.7%, 20.8%, 22.4%, and 25.9%, respectively. Despite a decline in HCV antibody-positive rates over time, the proportion requiring referral remained high.

Conclusions: Although the number of HCV antibody-positive patients in ophthalmology departments has decreased, a considerable proportion could still be considered for DAA therapy. Combining HCV antibody titer determination with EMR review improves the efficiency of identifying patients requiring referral.

查看原文本刊更多论文

通过眼科手术术前检测确定的丙型肝炎病毒抗体阳性患者可考虑接受直接抗病毒治疗的比例趋势：日本一项全国多中心真实世界队列研究

背景和目的：尽管直接作用抗病毒药物（DAAs）的广泛使用降低了丙型肝炎病毒（HCV）抗体阳性患者接受抗病毒治疗的比例，但目前在检测量高、HCV抗体阳性率高的眼科，需要转诊DAA治疗的比例尚不清楚。方法：这项全国性多中心回顾性队列研究纳入了2019年至2023年期间在日本20家机构眼科通过检测发现的HCV抗体阳性患者。通过所有20家机构的电子病历（EMR）审查和9家可测量抗体滴度的机构的EMR审查和HCV抗体滴度测定相结合，评估了需要转诊DAA治疗的患者比例。结果：20家机构共发现2792例HCV抗体阳性患者。根据EMR回顾，2019年、2020年、2021年、2022年和2023年，需要转诊DAA治疗的比例分别为44.4%、38.7%、34.2%、38.9%和42.5%。在9家可检测HCV抗体滴度的机构的1255例HCV抗体阳性患者中，EMR评价和抗体滴度联合评估的相应比例分别为28.4%、23.7%、20.8%、22.4%和25.9%。尽管随着时间的推移，HCV抗体阳性率有所下降，但需要转诊的比例仍然很高。结论：虽然眼科HCV抗体阳性患者数量有所下降，但仍有相当比例的患者可考虑采用DAA治疗。将HCV抗体滴度测定与EMR评价相结合可提高识别需要转诊患者的效率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Hepatology Research 医学-胃肠肝病学

CiteScore

8.30

自引率

14.30%

发文量

124

审稿时长

1 months

期刊介绍： Hepatology Research (formerly International Hepatology Communications) is the official journal of the Japan Society of Hepatology, and publishes original articles, reviews and short comunications dealing with hepatology. Reviews or mini-reviews are especially welcomed from those areas within hepatology undergoing rapid changes. Short communications should contain concise definitive information.