Regioselective Hydroxyesterification of Electron-Rich Alkenes Enabled by Bifunctional mCPBA

IF 4.5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2026-09-17 DOI:10.1039/d6qo00700g

Jaewon Seo,Soogyum Kim,Suji Lee,Jeonghyo Lee

引用次数: 0

Abstract

A regioselective hydroxyesterification of electron-rich alkenes is achieved through the dual role of mCPBA as oxidant and ring-opening nucleophile precursor. Hydroxyesters are obtained with broad scope and high reaction mass efficiency. Mechanistic studies support acid-promoted epoxide activation, where regioselectivity arises from substrate electronics and developing cationic character.

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双功能mCPBA催化富电子烯烃的区域选择性羟基酯化

通过mCPBA作为氧化剂和开环亲核前体的双重作用，实现了富电子烯烃的区域选择性羟基酯化。反应范围广，反应质量效率高。机理研究支持酸促进环氧化物活化，其中区域选择性源于衬底电子和发展的阳离子特性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.