Clinical and hematological profiles of patients with burning mouth syndrome across international cohorts: a multicenter study.

IF 5.4 4区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Cranio-The Journal of Craniomandibular & Sleep Practice Pub Date : 2026-09-12 DOI:10.1080/08869634.2026.2729201

Taku Kimura, Camila de Barros Gallo, Gennaro Musella, Daniela Adamo, Ken-Ichiro Sakata, Tougo Tanabe, Liliane Novaes Joaquim, Fabio Abreu Alves, Alessandro Villa

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引用次数: 0

Abstract

Objective: The aim of this study was to evaluate differences among patients with Burning Mouth Syndrome (BMS) in hematological parameters and clinical features, and to assess their associations with BMS symptoms.

Methods: This multicenter retrospective study included 348 patients from Brazil, Italy, Japan, and United States. Clinical and hematological characteristics were compared across populations ; logistic regression assessed associations with severe symptoms.

Results: The cohort comprised 181 Asians (52.0%), 130 Whites (37.4%), 22 Hispanics (6.3%), and 15 Blacks (4.3%), with significant differences in age, occupations and social history. Most hematological parameters were not associated with symptom severity; psychotropic medication use was the only factor significantly associated with severe symptoms in both Whites (p < .0001) and Asians (p = .0098).

Conclusion: BMS exhibits population-related variability in hematological and clinical profiles. Psychological factorsmay be associated with symptom severity, whereas hematological parameters were not, highlighting the importance of considering population-related characteristics in clinical management.

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国际队列中灼口综合征患者的临床和血液学特征：一项多中心研究。

目的：本研究的目的是评估灼口综合征（BMS）患者血液学参数和临床特征的差异，并评估其与BMS症状的相关性。方法：这项多中心回顾性研究包括来自巴西、意大利、日本和美国的348例患者。比较不同人群的临床和血液学特征；Logistic回归评估与严重症状的关联。结果：亚裔181人（52.0%）、白人130人（37.4%）、西班牙裔22人（6.3%）、黑人15人（4.3%），年龄、职业、社会历史差异显著。大多数血液学参数与症状严重程度无关；精神药物的使用是两种白人中与严重症状显著相关的唯一因素（p p = 0.0098）。结论：BMS在血液学和临床方面表现出与人群相关的变异性。心理因素可能与症状严重程度有关，而血液学参数则无关，这突出了在临床管理中考虑人群相关特征的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cranio-The Journal of Craniomandibular & Sleep Practice DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

4.50

自引率

12.50%

发文量

审稿时长

>12 weeks

期刊介绍： CRANIO: The Journal of Craniomandibular & Sleep Practice is the oldest and largest journal in the world devoted to temporomandibular disorders, and now also includes articles on all aspects of sleep medicine. The Journal is multidisciplinary in its scope, with editorial board members from all areas of medicine and dentistry, including general dentists, oral surgeons, orthopaedists, radiologists, chiropractors, professors and behavioural scientists, physical therapists, acupuncturists, osteopathic and ear, nose and throat physicians. CRANIO publishes commendable works from outstanding researchers and clinicians in their respective fields. The multidisciplinary format allows individuals practicing with a TMD emphasis to stay abreast of related disciplines, as each issue presents multiple topics from overlapping areas of interest. CRANIO''s current readership (thousands) is comprised primarily of dentists; however, many physicians, physical therapists, chiropractors, osteopathic physicians and other related specialists subscribe and contribute to the Journal.