Effects of light on brain-state dynamics and energy landscape.

Abstract

Light influences human cognition and behavior, and neuroimaging studies show that brain activity is modulated by light intensity. However, how light affects temporal brain-state transitions and the control energy required for these transitions remains unclear. To investigate this, we applied a network control theory approach to fMRI data collected from 20 healthy participants who performed an auditory discrimination task under four light intensities. Despite similar task performance, higher light intensity increased the number of transitions between brain states. Increasing light intensity enhanced the occurrence of a visual network dominated brain state, while decreasing the occurrence of brain states characterized by suppressed default mode activity and elevated frontoparietal activity. Furthermore, light intensity affected transition probabilities among different brain states contributed by redistributions of energy demands with the dorso-posterior thalamus appearing to play a key role in mediating light-related effects. Regionally, higher light intensity was associated with a trend toward reduced control energy in the visual network; frontal, cingulate, and insular cortices; and caudate and task-related regions, while showing a trend toward increased control energy in the somatomotor network and temporal pole. These findings suggest that high-intensity light may enhance neural efficiency and flexibility by redistributing control energy demands across brain regions.