Post-traumatic stress disorder following intensive care for COVID-19: a single-center retrospective follow-up study.

IF 3.2 3区医学 Q2 ANESTHESIOLOGY

BMC Anesthesiology Pub Date : 2026-09-12 DOI:10.1186/s12871-026-04256-2

Carsten Zeiner, Pascal D Schmitt, Julius J Weise, Torben M Rixecker, Robert Bals, Philipp M Lepper

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引用次数: 0

Abstract

Background: Severe COVID-19 frequently required prolonged intensive care, including mechanical ventilation or extracorporeal membrane oxygenation (ECMO). Survivors of such critical illness may develop post-traumatic stress disorder (PTSD).

Methods: We conducted a single-center retrospective follow-up study of COVID-19 ICU survivors at Saarland University Medical Center, Germany, assessing ICD-11 trauma-related disorders using the validated International Trauma Questionnaire (ITQ) and analyzing associations with clinical factors.

Results: Of 110 eligible patients, 42 (38.2%) valid datasets were obtained. The overall prevalence of ICD-11 trauma-related disorders (PTSD or CPTSD) was 23.8% (95% CI 12.1-39.5%; n = 10), with PTSD diagnosed in 6 participants (14.3%; 95% CI 5.4-28.5%) and CPTSD in 4 participants (9.5%; 95% CI 2.7-22.6%). No statistically significant associations were found for any of the examined variables. Exploratory subgroup analyses revealed numerically higher rates of trauma-related disorders in patients with prior psychiatric treatment (40.0% vs. 21.6%), ECMO therapy (33.3% vs. 16.7%), or renal replacement therapy (50.0% vs. 17.6%); however, these findings should be interpreted with caution given the limited sample size.

Conclusions: Nearly one quarter of COVID-19 ICU survivors met the diagnostic criteria for PTSD or CPTSD, a prevalence comparable to that observed in other critically ill populations. No statistically significant associations were identified, and the observed subgroup differences should be regarded as exploratory and hypothesis-generating. The reported prevalence of PTSD/CPTSD highlights the potential value of systematic screening for trauma-related disorder and the integration of psychological support into post-ICU care. Larger prospective multicenter studies are needed to confirm these findings and further characterize potential risk factors.

Trial registration: The study was reviewed and approved by the Ethics committee of the Medical Association of Saarland (Number 98/22).

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COVID-19重症监护后创伤后应激障碍：单中心回顾性随访研究

背景：重症COVID-19通常需要长时间的重症监护，包括机械通气或体外膜氧合（ECMO）。这种严重疾病的幸存者可能会发展为创伤后应激障碍（PTSD）。方法：对德国萨尔大学医学中心的COVID-19 ICU幸存者进行单中心回顾性随访研究，采用经验证的国际创伤问卷（ITQ）评估ICD-11创伤相关障碍，并分析其与临床因素的相关性。结果：在110例符合条件的患者中，获得42例（38.2%）有效数据集。ICD-11创伤相关障碍（PTSD或CPTSD）的总体患病率为23.8% (95% CI 12.1-39.5%; n = 10)，其中6名参与者被诊断为PTSD (14.3%; 95% CI 5.4-28.5%)， 4名参与者被诊断为CPTSD （9.5%; 95% CI 2.7-22.6%）。没有发现任何被检查的变量有统计学意义的关联。探索性亚组分析显示，先前接受过精神科治疗（40.0%对21.6%）、ECMO治疗（33.3%对16.7%）或肾脏替代治疗（50.0%对17.6%）的患者出现创伤相关疾病的比例较高；然而，考虑到有限的样本量，这些发现应该谨慎解释。结论：近四分之一的COVID-19 ICU幸存者符合PTSD或CPTSD的诊断标准，这一患病率与其他危重患者人群的患病率相当。未发现有统计学意义的关联，观察到的亚组差异应被视为探索性和假设生成。PTSD/CPTSD患病率的报道强调了系统筛查创伤相关障碍和将心理支持整合到icu后护理中的潜在价值。需要更大规模的前瞻性多中心研究来证实这些发现，并进一步确定潜在的危险因素。试验注册：该研究由萨尔州医学协会伦理委员会审查并批准（第98/22号）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Anesthesiology ANESTHESIOLOGY-

CiteScore

3.50

自引率

4.50%

发文量

349

审稿时长

>12 weeks

期刊介绍： BMC Anesthesiology is an open access, peer-reviewed journal that considers articles on all aspects of anesthesiology, critical care, perioperative care and pain management, including clinical and experimental research into anesthetic mechanisms, administration and efficacy, technology and monitoring, and associated economic issues.