Selective potentiation of NaV1.1 channels by Small Molecule XPC-A in Dravet mice suppresses spontaneous seizures, prevents SUDEP, and increases Long Term Potentiation

IF 7.4 2区医学 Q1 CLINICAL NEUROLOGY

Neurotherapeutics Pub Date : 2026-07-01 Epub Date: 2026-09-09 DOI:10.1016/j.neurot.2026.e01015

Samuel Goodchild PhD, Kristen Burford PhD, Celine Dube PhD, Samrat Thouta PhD, Arjun Mahadevan PhD, Matt Waldbrook, Maegan Soriano, Maja Filipovic, Vishaal Rajani PhD, Emily Hurley PhD, Sarah Bryan, Verner Lofstrand PhD, Helen Clement PhD, Davie Kim, Steven Wesolowski, Alison Cutts PhD, James Empfield PhD, J.P. Johnson PhD

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小分子XPC-A选择性增强Dravet小鼠NaV1.1通道抑制自发性癫痫发作，预防SUDEP，并增加长期增强

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来源期刊

Neurotherapeutics 医学-神经科学

CiteScore

11.00

自引率

3.50%

发文量

154

审稿时长

6-12 weeks

期刊介绍： Neurotherapeutics® is the journal of the American Society for Experimental Neurotherapeutics (ASENT). Each issue provides critical reviews of an important topic relating to the treatment of neurological disorders written by international authorities. The Journal also publishes original research articles in translational neuroscience including descriptions of cutting edge therapies that cross disciplinary lines and represent important contributions to neurotherapeutics for medical practitioners and other researchers in the field. Neurotherapeutics ® delivers a multidisciplinary perspective on the frontiers of translational neuroscience, provides perspectives on current research and practice, and covers social and ethical as well as scientific issues.