Interferon regulatory factors orchestrate CD8⁺ T cell function (Review).

IF 8.5 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

International journal of molecular medicine Pub Date : 2026-11-01 Epub Date: 2026-09-11 DOI:10.3892/ijmm.2026.5982

Fa-Xi Wang, Chun-Liang Yang, Shan-Jie Rong, Qi-Jie Chen, Xiong-Tao Yue, Fei Sun

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引用次数: 0

Abstract

The fate of CD8⁺ T cells is dictated by epigenetic remodeling, metabolic rewiring and most critically, the transcriptional reprogramming that integrates diverse extracellular signaling pathways. Transcription factors (TFs) predetermine cell differentiation state and lineage‑specifying hub TFs are decisive for CD8⁺ T cell functional maturation. The present study aimed to summarize the indispensable roles of interferon regulatory factors (IRFs) in CD8⁺ T cell biology from early thymic development to the acquisition of distinct functional states. Alone or together with other TFs, IRFs are involved in the regulation of CD8⁺ T cell commitment, effector differentiation, memory maintenance and terminal exhaustion. In clinical practice, IRF family members hold potential as prognostic biomarkers and valuable therapeutic targets in CD8⁺ T cell‑associated immune disorders, such as tumors, transplant rejection, infection and autoinflammatory diseases.

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干扰素调节因子协调CD8+ T细胞的功能。

CD8+ T细胞的命运由表观遗传重塑、代谢重布线和最关键的转录重编程决定，转录重编程整合了多种细胞外信号通路。转录因子（TFs）预先决定细胞分化状态，谱系指定枢纽TFs对CD8+ T细胞功能成熟具有决定性作用。本研究旨在总结干扰素调节因子（IRFs）在CD8+ T细胞从早期胸腺发育到获得不同功能状态的生物学过程中不可或缺的作用。irf单独或与其他tf一起参与CD8+ T细胞承诺、效应物分化、记忆维持和终末衰竭的调节。在临床实践中，IRF家族成员在CD8+ T细胞相关免疫疾病（如肿瘤、移植排斥、感染和自身炎症性疾病）中具有作为预后生物标志物和有价值的治疗靶点的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International journal of molecular medicine 医学-医学：研究与实验

CiteScore

12.30

自引率

0.00%

发文量

124

审稿时长

3 months

期刊介绍： The main aim of Spandidos Publications is to facilitate scientific communication in a clear, concise and objective manner, while striving to provide prompt publication of original works of high quality. The journals largely concentrate on molecular and experimental medicine, oncology, clinical and experimental cancer treatment and biomedical research. All journals published by Spandidos Publications Ltd. maintain the highest standards of quality, and the members of their Editorial Boards are world-renowned scientists.