Colour Doppler US assessment of retrobulbar hemodynamics and static retinal vessel analysis in Sjögren's disease: the SICARD cohort.

IF 4.7 2区医学 Q1 RHEUMATOLOGY

Rheumatology Pub Date : 2026-10-01 DOI:10.1093/rheumatology/keag493

Konstantinos Triantafyllias, Veronika Balaklytska, Elsa Wilma Boehm, Andreas V Goules, Elena Joerns, Paraskevi V Voulgari, Elena Bartoloni, Lorenzo Cavagna, Sarah Wagner, Mohammed Alhaddad, Andreas Schwarting

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引用次数: 0

Abstract

Objectives: To assess, for the first time, macrovascular, medium-calibre vessel and microvascular damage in Sjögren's disease (SjD) using carotid greyscale US (GSUS), retrobulbar colour Doppler ophthalmic artery (OA) US (RCDUS) and static retinal vessel analysis (SRVA). Additionally, to evaluate associations of these markers with cardiovascular (CV) risk factors, patient- and disease-related characteristics.

Methods: GSUS of the common carotid arteries was performed to measure carotid intima-media thickness (cIMT) and evaluate plaque burden. RCDUS assessed OA flow velocity integral (FVI), resistive and pulsatility indices (RI, PI). SRVA quantified retinal microvasculature using central retinal arteriolar, venular equivalents (CRAE, CRVE) and the arteriovenous ratio (AVR). Imaging findings were compared between patients with SjD and healthy controls and analysed in relation to clinical parameters.

Results: 130 SjD patients and 100 controls were included. SjD patients showed significantly higher cIMT (Padj = 0.003), OA-RI (Padj = 0.003) and -PI (Padj < 0.001), as well as lower OA-FVI (Padj = 0.012) and CRAE (Padj = 0.013) compared with the controls. Higher OA-RI and -PI correlated with higher disease activity (ESSDAI: both; rho = 0.324, P = 0.006), and impaired renal function (rho = -0.461, P < 0.001 and rho = -0.370, P = 0.002, respectively). OA-RI associated positively with age (rho = 0.435, P < 0.001) and inversely with lung carbon monoxide diffusion (r = -0.342, P = 0.019). Lower CRAE correlated with higher mean arterial pressure (r = -0.378, P < 0.001), CRP (rho = -0.215, P = 0.046), ANA titre (rho = -0.268, P = 0.016) and disease activity (ESSDAI: rho = -0.273, P = 0.011).

Conclusions: In this first comprehensive study of CV surrogate markers in SjD, patients exhibited vascular alterations across multiple vascular beds, indicating systemic vascular involvement and a possible link to increased CV and cerebrovascular risk.

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彩色多普勒超声评估Sjögren疾病的球后血流动力学和静态视网膜血管分析：SICARD队列。

目的：首次应用颈动脉灰度超声（GSUS）、球后彩色多普勒眼动脉（OA）超声（RCDUS）和静态视网膜血管分析（SRVA）评估Sjögren病（SjD）的大血管、中径血管和微血管损伤。此外，评估这些标志物与心血管（CV）危险因素、患者和疾病相关特征的相关性。方法：采用颈总动脉GSUS测量颈动脉内膜-中膜厚度（cIMT），评价斑块负荷。RCDUS评估OA流速积分（FVI），电阻和脉搏指数（RI， PI）。SRVA量化视网膜微血管使用中央视网膜小动脉，静脉当量（CRAE， CRVE）和动静脉比（AVR）。比较SjD患者与健康对照者的影像学表现，并分析其与临床参数的关系。结果：纳入SjD患者130例，对照组100例。SjD患者的cIMT （padj=0.003）、OA-RI （padj=0.003）和-PI （padj）均显著升高。结论：在这项SjD中CV替代标志物的首次综合研究中，患者表现出跨多个血管床的血管改变，表明全身血管受累，可能与心脑血管风险增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Rheumatology 医学-风湿病学

CiteScore

9.40

自引率

7.30%

发文量

1091

审稿时长

2 months

期刊介绍： Rheumatology strives to support research and discovery by publishing the highest quality original scientific papers with a focus on basic, clinical and translational research. The journal’s subject areas cover a wide range of paediatric and adult rheumatological conditions from an international perspective. It is an official journal of the British Society for Rheumatology, published by Oxford University Press. Rheumatology publishes original articles, reviews, editorials, guidelines, concise reports, meta-analyses, original case reports, clinical vignettes, letters and matters arising from published material. The journal takes pride in serving the global rheumatology community, with a focus on high societal impact in the form of podcasts, videos and extended social media presence, and utilizing metrics such as Altmetric. Keep up to date by following the journal on Twitter @RheumJnl.