Pyroptotic pores reopen the case for caspase inhibitors.
IF 24
1区 医学
Q1 PHARMACOLOGY & PHARMACY
Trends in pharmacological sciences
Pub Date : 2026-10-01
Epub Date: 2026-09-09
DOI:10.1016/j.tips.2026.08.013
引用次数: 0
Abstract
Caspase inhibitors have repeatedly entered clinical trials but have not reached clinical practice due to toxicity and limited efficacy. Groborz and colleagues now show that gasdermin D pores admit otherwise membrane-impermeable inhibitors into pyroptotic cells, turning poor permeability into a mechanism of cell-state selectivity.
半胱天冬酶抑制剂的热腐孔重新打开。
Caspase抑制剂多次进入临床试验，但由于其毒性和疗效有限，尚未进入临床实践。Groborz和他的同事们现在表明，气真皮蛋白D的孔隙允许其他膜不渗透性抑制剂进入热亡细胞，将渗透性差转化为细胞状态选择性的机制。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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来源期刊
CiteScore
23.90
自引率
0.70%
发文量
132
审稿时长
6-12 weeks
期刊介绍：
Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research.
The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics.
Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles.
Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.
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