[Pancreatic atrophy and pancreatic exocrine insufficiency after allogeneic hematopoietic stem cell transplantation: a case report and literature review].

Abstract

A 60-year-old male patient with acute B-cell lymphoblastic leukemia received allogeneic hematopoietic stem cell transplantation from an unrelated donor. He was transplanted with 6.22×10(8) mononuclear cells/kg and 6.27×10(6) CD34(+) cells/kg, and engraftment was confirmed at +11 days. Eighteen months post-transplant, the patient developed persistent diarrhea and continued weight loss, which was unresponsive to antidiarrheal, immunosuppressive, and antimicrobial treatments. After abdominal CT, pancreatic magnetic resonance imaging, and fecal elastase-1 tests, he was diagnosed with pancreatic atrophy and severe pancreatic exocrine insufficiency. Symptoms significantly improved following pancreatic enzyme replacement therapy.