Characteristics and Hospitalization Details of Patients with Advanced Parkinson's Disease Receiving Continuous Subcutaneous Infusion of Foslevodopa/Foscarbidopa: Real-World First-Year Descriptive Study from Japan.

IF 4.7 3区医学 Q1 CLINICAL NEUROLOGY

Neurology and Therapy Pub Date : 2026-09-04 DOI:10.1007/s40120-026-01016-9

Toru Baba, Toshiki Nozaki, Shunji Toya, Hideyuki Migita, Kairi Ri, Atsushi Takeda

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Abstract

Introduction: The real-world characteristics of patients with advanced Parkinson's disease (PD) who receive foslevodopa/foscarbidopa (LDp/CDp) continuous subcutaneous infusion therapy (CSCI) remain poorly understood. This study aimed to describe the characteristics and hospitalization details of patients with advanced PD hospitalized for LDp/CDp CSCI in Japan.

Methods: This study was a retrospective descriptive analysis conducted using a hospital-based database provided by Medical Data Vision, Co. Ltd. Patients with advanced PD who underwent LDp/CDp CSCI during hospitalization between July 2023 and June 2024 were enrolled. The index date was defined as the date of the first LDp/CDp prescription. Baseline patient characteristics, levodopa-equivalent dose (LED), number of pills/transdermal patches, medication classes for concomitant PD medications, and non-motor symptom medications assessed within 4 weeks prior to and including the index date, along with hospitalization details, were collected.

Results: We enrolled 96 patients with a mean age of 65.6 years [standard deviation (SD), 10.2], of whom 58 (60.4%) were female. The median Barthel Index was 90.0 [interquartile range (IQR): 44.2], and the hospitalization duration was 15.0 days (IQR: 9.0). Eighteen patients (18.8%) discontinued LDp/CDp CSCI during hospitalization. The mean LED of any PD medications prior to LDp/CDp CSCI initiation, the mean number of PD medication classes, and the daily pill/transdermal patch count for PD medications were 1,111.0 mg/day (SD 575.7), 3.9 (SD 1.3), and 10.6 (SD 5.0), respectively. Except for levodopa (L-Dopa), dopamine agonists (78.1%) were the most commonly used concomitant PD medications.

Conclusions: In real-world clinical practice in Japan, patients with LDp/CDp CSCI tend to be younger and have preserved activities of daily living. Our results implied that patients are often managed with multiple concomitant PD medications rather than with L-Dopa dose titration prior to initiation. Further research is warranted to maximize the benefits of LDp/CDp CSCI and assess its real-world impact on pill burden.

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持续皮下输注Foslevodopa/Foscarbidopa的晚期帕金森病患者的特征和住院细节：来自日本的真实世界第一年描述性研究

导读：接受foslevodopa/foscarbidopa （LDp/CDp）持续皮下输注治疗（CSCI）的晚期帕金森病（PD）患者的现实世界特征仍然知之甚少。本研究旨在描述日本晚期PD患者因LDp/CDp CSCI住院的特点和住院细节。方法：本研究采用回顾性描述性分析，采用医疗数据视觉有限公司提供的医院数据库。研究纳入了2023年7月至2024年6月住院期间接受LDp/CDp CSCI的晚期PD患者。索引日期定义为第一个LDp/CDp处方的日期。收集基线患者特征、左旋多巴等效剂量（LED）、药片/透皮贴片数量、伴随PD药物的药物类别、在索引日期之前和包括索引日期在内的4周内评估的非运动症状药物，以及住院详细信息。结果：我们纳入96例患者，平均年龄65.6岁[标准差（SD）， 10.2]，其中58例（60.4%）为女性。Barthel指数中位数为90.0[四分位差（IQR）： 44.2]，住院时间为15.0 d （IQR: 9.0）。18例患者（18.8%）在住院期间停止了LDp/CDp CSCI。在LDp/CDp CSCI开始之前，PD药物的平均LED、PD药物类别的平均数量和PD药物的每日药丸/透皮贴片计数分别为1111.0 mg/天（SD 575.7）、3.9 mg/天（SD 1.3）和10.6 mg/天（SD 5.0）。除左旋多巴（L-Dopa）外，多巴胺激动剂（78.1%）是最常用的PD伴随药物。结论：在日本的实际临床实践中，LDp/CDp CSCI患者往往更年轻，并且保留了日常生活活动。我们的研究结果表明，患者通常使用多种伴随PD药物治疗，而不是在开始治疗前使用左旋多巴剂量滴定。有必要进行进一步的研究，以最大限度地提高LDp/CDp CSCI的效益，并评估其对药片负担的实际影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurology and Therapy CLINICAL NEUROLOGY-

CiteScore

5.40

自引率

8.10%

发文量

103

审稿时长

6 weeks

期刊介绍： Aims and Scope Neurology and Therapy aims to provide reliable and inclusive, rapid publication for all therapy related research for neurological indications, supporting the timely dissemination of research with a global reach, to help advance scientific discovery and support clinical practice. Neurology and Therapy is an international, open access, peer reviewed, rapid publication journal dedicated to the publication of high-quality clinical (all phases), observational, real-world and health outcomes research around the discovery, development, and use of neurological and psychiatric therapies, (also covering surgery and devices). Studies relating to diagnosis, pharmacoeconomics, public health, quality of life, and patient care, management, and education are also welcomed. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, case reports, trial designs, communications and letters. 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