Performance evaluation of a dedicated brain PET scanner with octagonal detector arrangement using a modified NEMA NU2 2018 protocol

IF 3.2 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Medical physics Pub Date : 2026-08-24 DOI:10.1002/mp.70578

Ekaterina Mikhaylova, Max L. Ahnen, Henryk Barthel, Jan Debus, Jannis Fischer, Martin Huellner, Markus Jehl, Philipp A. Kaufmann, Michael Rullmann, Bernhard Sattler, Karen G. Steinhoff, Juan Streb, Solveig Tiepolt, Valerie Treyer, Osama Sabri, Ilaria Sacco

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引用次数: 0

Abstract

Background

This work presents the NEMA NU2 2018 performance evaluation of the NeuroLF Basic, a compact and fully integrated brain positron emission tomography (PET) system based on 10-mm-long LYSO crystals.

Purpose

The goal is to assess its quantitative performance and imaging capabilities for neuroimaging applications.

Methods

The evaluation includes measurements and simulations of spatial resolution, scatter fraction, noise equivalent count rate (NECR), accuracy of corrections, image quality, and sensitivity, following standardized protocols to ensure reliable and reproducible results. In addition, imaging of the Hoffman 3-dimensional brain phantom was performed to visually evaluate system performance. Image quality was assessed using an ACR Esser phantom, which fits within the compact bore of the NeuroLF scanner.

Results

The average filtered-back-projection spatial resolution, measured at 1 and 10 cm radial offsets, was 2.51 and 3.61 mm, respectively, highlighting the system's ability to capture details essential for neuroimaging. The scatter fraction was 24.2% at the peak NECR, reflecting the system's capability to minimize scattered events. The peak NECR was 55.3 kcps at an activity concentration of 8.1 kBq/mL, demonstrating the system's efficiency in handling typical neuroimaging count rates. NeuroLF showed excellent accuracy of corrections at 3.7% and good image contrast for hot vials in a warm background in the adapted image quality procedure with the ACR Esser phantom, achieving values of 87.5%, 77%, 60%, and 35.8% for 25-, 16-, 12-, and 8-mm-diameter vials, respectively, with a maximum background variability of 10% for the 8-mm vial. Sensitivity, evaluated using a 70-cm line source, was 5.85 cps/kBq at the center of the field of view and 8.08 cps/kBq at a 10 cm radial offset. Images of the Hoffman phantom further demonstrated the system's ability to produce realistic brain uptake distributions. The measured NEMA NU2 2018 results showed good agreement with Monte Carlo simulation results, validating the simulated NeuroLF model for future research and optimization.

Conclusions

These results demonstrate the NeuroLF's potential to deliver high-quality images, good detection efficiency, and robust quantitative performance. The comprehensive NEMA NU2 2018 evaluation, supported by Hoffman phantom imaging, confirms NeuroLF's capability as a valuable tool for clinical applications in neuroimaging.

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使用改进的NEMA NU2 2018协议对具有八边形探测器配置的专用脑PET扫描仪进行性能评估。

背景：本工作介绍了NEMA NU2 2018对NeuroLF Basic的性能评估，NeuroLF Basic是一种基于10mm长LYSO晶体的紧凑且完全集成的脑正电子发射断层扫描（PET）系统。目的：目的是评估其定量性能和成像能力的神经影像学应用。方法：评估包括空间分辨率、散射分数、噪声等效计数率（NECR）、校正精度、图像质量和灵敏度的测量和模拟，遵循标准化方案，以确保可靠和可重复的结果。此外，霍夫曼三维脑幻影成像进行视觉评估系统性能。使用ACR Esser模体评估图像质量，该模体安装在NeuroLF扫描仪的紧凑孔内。结果：在1 cm和10 cm径向偏移处测量的平均滤波后投影空间分辨率分别为2.51和3.61 mm，突出了该系统捕捉神经成像所需细节的能力。在NECR峰值时，散射分数为24.2%，反映了系统对散射事件的最小化能力。当活性浓度为8.1 kBq/mL时，峰值NECR为55.3 kcps，证明了该系统在处理典型神经成像计数率方面的效率。在ACR Esser幻影的适应图像质量程序中，在温暖背景下，对于热瓶，NeuroLF显示出3.7%的极好校正精度和良好的图像对比度，对于25、16、12和8mm直径的小瓶，分别达到87.5%、77%、60%和35.8%，对于8mm小瓶，最大背景变异性为10%。使用70厘米线源评估的灵敏度在视场中心为5.85 cps/kBq，在10厘米径向偏移处为8.08 cps/kBq。霍夫曼幻像的图像进一步证明了该系统产生真实的大脑摄取分布的能力。NEMA NU2 2018的实测结果与蒙特卡罗仿真结果吻合较好，验证了仿真NeuroLF模型的有效性，为未来的研究和优化提供了依据。结论：这些结果表明NeuroLF具有提供高质量图像、良好检测效率和稳健定量性能的潜力。在Hoffman幻影成像的支持下，NEMA NU2 2018的综合评估证实了NeuroLF作为神经成像临床应用的宝贵工具的能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical physics 医学-核医学

CiteScore

6.80

自引率

15.80%

发文量

660

审稿时长

1.7 months

期刊介绍： Medical Physics publishes original, high impact physics, imaging science, and engineering research that advances patient diagnosis and therapy through contributions in 1) Basic science developments with high potential for clinical translation 2) Clinical applications of cutting edge engineering and physics innovations 3) Broadly applicable and innovative clinical physics developments Medical Physics is a journal of global scope and reach. By publishing in Medical Physics your research will reach an international, multidisciplinary audience including practicing medical physicists as well as physics- and engineering based translational scientists. We work closely with authors of promising articles to improve their quality.