Pooja Karandikar, Rebecca Carter, Sudhir Vashist, Paula G Newton
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Abstract
Summary: Amiodarone-induced thyrotoxicosis (AIT) is a known complication of amiodarone usage in adults that occurs secondary to unregulated overproduction of thyroid hormone due to excess iodine exposure in an abnormal thyroid gland (type one), the release of stored thyroid hormone due to a direct cytotoxic effect on a normal thyroid gland (type two), or both (mixed type). Therapy for AIT depends on the subtype present and typically consists of discontinuation of amiodarone and the addition of thyrostatic drugs or corticosteroids. AIT is a very uncommon adverse side effect of amiodarone use in children. We discuss a pediatric patient with a history of complex congenital heart defects and ventricular arrhythmia treated with amiodarone who developed AIT. This case illustrates the importance of regular thyroid function monitoring with clear guidelines, especially for pediatric patients, and the need for improved education regarding this phenomenon.
期刊介绍：
Endocrinology, Diabetes & Metabolism Case Reports publishes case reports on common and rare conditions in all areas of clinical endocrinology, diabetes and metabolism. Articles should include clear learning points which readers can use to inform medical education or clinical practice. The types of cases of interest to Endocrinology, Diabetes & Metabolism Case Reports include: -Insight into disease pathogenesis or mechanism of therapy - Novel diagnostic procedure - Novel treatment - Unique/unexpected symptoms or presentations of a disease - New disease or syndrome: presentations/diagnosis/management - Unusual effects of medical treatment - Error in diagnosis/pitfalls and caveats
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