Trojan mast cells: repurposing allergy for targeted oncolytic delivery.

IF 24 1区医学 Q1 PHARMACOLOGY & PHARMACY

Trends in pharmacological sciences Pub Date : 2026-09-01 Epub Date: 2026-08-18 DOI:10.1016/j.tips.2026.08.001

Mengqin Guo, Wenhao Wang, Zhengwei Huang

引用次数: 0

Abstract

Oncolytic viruses hold immense therapeutic promise but face formidable systemic delivery barriers. A new study by Xu et al. engineered immunoglobulin E-sensitized mast cells to selectively ferry these viruses into tumors. Excitingly, antigen-triggered degranulation precisely releases the viral payload and reshapes the immune microenvironment, offering a highly modular delivery paradigm.

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特洛伊肥大细胞：重新利用过敏靶向溶瘤传递。

溶瘤病毒具有巨大的治疗前景，但面临巨大的全身输送障碍。Xu等人的一项新研究设计了免疫球蛋白e致敏的肥大细胞，选择性地将这些病毒运送到肿瘤中。令人兴奋的是，抗原触发的脱颗粒精确地释放病毒有效载荷并重塑免疫微环境，提供高度模块化的递送范式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in pharmacological sciences 医学-药学

CiteScore

23.90

自引率

0.70%

发文量

132

审稿时长

6-12 weeks

期刊介绍： Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research. The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics. Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles. Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.