[Arterial hypertension and bronchial asthma: phenotype, cardiovascular complications, and independent predictors - an analysis of 57,396 patients from a hypertension registry].

IF 0.3 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Terapevticheskii Arkhiv Pub Date : 2026-08-18 DOI:10.26442/00403660.2026.08.203727

A V Aksenova, R S Makaryan, I S Serov, O A Belova, S A Rachkova, I E Chazova

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引用次数: 0

Abstract

Background: The combination of arterial hypertension (AH) and bronchial asthma (BA) presents a complex clinical challenge that notably elevates cardiovascular risk. Real-world data are scarce regarding the phenotype and incidence of cardiovascular complications within this patient population.

Aim: To investigate the prevalence of cardiovascular risk factors and comorbidities in patients with AH, taking into account the presence of BA, as recorded in the national hypertension registry.

Materials and methods: Retrospective analysis of a hypertension registry: 56,784 AH patients without BA and 612 with AH+BA. Demographic and anthropometric parameters and comorbidity prevalence were compared. Odds ratios (OR) were adjusted for sex and age.

Results: BA prevalence was 1.1%. The AH+BA phenotype was characterized by female predominance (71.4% vs 59.4%; p<0.001), older age (65.0 years vs 62.7 years; p<0.001), higher BMI (29.4 kg/m² vs 28.5 kg/m²; p=0.002), and abdominal obesity (53.7% vs 39.0%; p=0.003). BA was associated with higher rates of coronary artery disease - CAD (56.2% vs 41.2%), chronic heart failure - CHF (68.8% vs 48.6%), and atrial fibrillation - AF (10.1% vs 4.3%; all p<0.001). After adjustment, BA remained an independent predictor of CAD (OR 2.02, 95% confidence interval - CI 1.71-2.40), CHF (OR 2.47, 95% CI 2.07-2.96), and AF (OR 2.49, 95% CI 1.88-3.23). No association with stroke was found.

Conclusion: The comorbidity of BA and AH is associated with a distinct phenotype (older woman with abdominal obesity). BA is an independent predictor of CAD, CHF, and AF, mandating active cardiovascular screening.

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[动脉高血压和支气管哮喘：表型、心血管并发症和独立预测因素——来自高血压登记的57,396例患者的分析]。

背景：动脉高血压（AH）和支气管哮喘（BA）合并是一个复杂的临床挑战，显著增加心血管风险。在这一患者群体中，关于心血管并发症的表型和发生率的实际数据很少。目的：研究国家高血压登记处记录的AH患者心血管危险因素和合并症的流行情况，并考虑BA的存在。材料和方法：回顾性分析高血压登记：56,784例无BA的AH患者和612例AH+BA患者。比较人口统计学和人体测量参数以及合并症患病率。根据性别和年龄调整优势比（OR）。结果：BA患病率为1.1%。AH+BA表型的特点是女性优势（71.4% vs 59.4%; pp2 vs 28.5 kg/m2; p=0.002）和腹部肥胖（53.7% vs 39.0%; p=0.003）。BA与冠心病（56.2%对41.2%）、慢性心力衰竭（68.8%对48.6%）和房颤（10.1%对4.3%）的高发率相关。结论：BA和AH的合并症与一种独特的表型（老年女性腹部肥胖）相关。BA是CAD、CHF和AF的独立预测因子，需要积极的心血管筛查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Terapevticheskii Arkhiv 医学-医学：内科

CiteScore

1.40

自引率

33.30%

发文量

171

审稿时长

3-8 weeks

期刊介绍： Терапевтический архив The journal was founded by the prominent Russian therapists M.P. Konchalovsky and G.F. Lang in 1923. Then its editors-in-chief were Professors V.N. Vinogradov and A.G. Gukasyan. Since 1972, E.I. Chazov, Academician of the Russian Academy of Sciences, has been heading the editorial board of the journal. Over 90 years, there have been more than 1000 issues where the authors and editorial staff have done their best for readers to keep abreast of current advances in medical science and practice and for physicians to master the advanced principles of recognition and treatment of a wide spectrum of visceral diseases. The papers published in the journal (editorials, original articles, lectures, reviews, etc.) cover both current scientific achievements and practical experience in diagnosing, treating, and preventing visceral diseases. The authors of publications are not only Russian, but also foreign scientists and physicians. All papers are peer-reviewed by highly qualified Russian specialists. The journal is published monthly. Traditionally, each issue has predominantly certain thematic areas covering individual therapy specializations. Every year, one of the issues is devoted to related problems in practical medicine (allergology and immunology, neurology and psychiatry, obstetrics, oncology, etc.). This all draws the attention of the reading public to the journal. The journal is indexed in RSCI (Russian Science Citation Index), PubMed/Medline, Index Medicus, Scopus/EMBASE, Web of Science Core Collection (Science Citation Index Expanded), Web of Science (Russian Science Citation Index - RSCI, Current Contents Connect, BIOSIS Previews), Google Scholar, Ulrich''s Periodicals Directory. The journal is included in the list of periodicals recommended by the Higher Attestation Committee for publishing the papers containing the basic materials of doctoral and candidate dissertations. By the decision of the Presidium of the Russian Academy of Medical Sciences, the “Therapevticheskiy Arkhiv” was awarded the Botkin medal. It was admitted to the European Association of Sciences Editors (EASE). The journal was honored with the Golden Press Fund decoration at the 13th International Press Professional Exhibition.