{"title":"[Еxosomes: possibilities and prospects in the diagnosis and treatment of digestive diseases].","authors":"I V Maev, M A Livzan, O V Gaus","doi":"10.26442/00403660.2026.08.203786","DOIUrl":null,"url":null,"abstract":"<p><p>Exosomes are extracellular membrane vesicles with a diameter of 30-150 nm secreted by various cell types into the extracellular environment and regulating many vital physiological processes, including signaling, immune activation, proliferation, differentiation, and apoptosis. Numerous studies conducted in recent years have demonstrated the key role of exosomes in the development of various gastrointestinal diseases, including cancer, allowing them to be considered as potentially promising diagnostic biomarkers. Furthermore, due to their inherent biocompatibility, ability to overcome biological barriers, low toxicity, and immunogenicity, exosomes can be used for targeted drug delivery in the treatment of patients with gastrointestinal diseases. This review article systematizes and presents information on exosomes, their functions, extraction and detection methods, and examines the main exosomal markers, which demonstrate significant potential for the diagnosis and treatment of various gastrointestinal diseases.</p>","PeriodicalId":22209,"journal":{"name":"Terapevticheskii Arkhiv","volume":"98 8","pages":"432-438"},"PeriodicalIF":0.3000,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Terapevticheskii Arkhiv","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.26442/00403660.2026.08.203786","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Exosomes are extracellular membrane vesicles with a diameter of 30-150 nm secreted by various cell types into the extracellular environment and regulating many vital physiological processes, including signaling, immune activation, proliferation, differentiation, and apoptosis. Numerous studies conducted in recent years have demonstrated the key role of exosomes in the development of various gastrointestinal diseases, including cancer, allowing them to be considered as potentially promising diagnostic biomarkers. Furthermore, due to their inherent biocompatibility, ability to overcome biological barriers, low toxicity, and immunogenicity, exosomes can be used for targeted drug delivery in the treatment of patients with gastrointestinal diseases. This review article systematizes and presents information on exosomes, their functions, extraction and detection methods, and examines the main exosomal markers, which demonstrate significant potential for the diagnosis and treatment of various gastrointestinal diseases.
期刊介绍：
Терапевтический архив
The journal was founded by the prominent Russian therapists M.P. Konchalovsky and G.F. Lang in 1923. Then its editors-in-chief were Professors V.N. Vinogradov and A.G. Gukasyan. Since 1972, E.I. Chazov, Academician of the Russian Academy of Sciences, has been heading the editorial board of the journal.
Over 90 years, there have been more than 1000 issues where the authors and editorial staff have done their best for readers to keep abreast of current advances in medical science and practice and for physicians to master the advanced principles of recognition and treatment of a wide spectrum of visceral diseases.
The papers published in the journal (editorials, original articles, lectures, reviews, etc.) cover both current scientific achievements and practical experience in diagnosing, treating, and preventing visceral diseases. The authors of publications are not only Russian, but also foreign scientists and physicians. All papers are peer-reviewed by highly qualified Russian specialists.
The journal is published monthly. Traditionally, each issue has predominantly certain thematic areas covering individual therapy specializations. Every year, one of the issues is devoted to related problems in practical medicine (allergology and immunology, neurology and psychiatry, obstetrics, oncology, etc.). This all draws the attention of the reading public to the journal.
The journal is indexed in RSCI (Russian Science Citation Index), PubMed/Medline, Index Medicus, Scopus/EMBASE, Web of Science Core Collection (Science Citation Index Expanded), Web of Science (Russian Science Citation Index - RSCI, Current Contents Connect, BIOSIS Previews), Google Scholar, Ulrich''s Periodicals Directory.
The journal is included in the list of periodicals recommended by the Higher Attestation Committee for publishing the papers containing the basic materials of doctoral and candidate dissertations.
By the decision of the Presidium of the Russian Academy of Medical Sciences, the “Therapevticheskiy Arkhiv” was awarded the Botkin medal. It was admitted to the European Association of Sciences Editors (EASE).
The journal was honored with the Golden Press Fund decoration at the 13th International Press Professional Exhibition.
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