A Catalogue of Dispensation Lengths for Building Treatment Episodes-Application of the Waiting Time Distribution to All Commonly Prescribed Drugs in Denmark.

IF 2.6 4区医学 Q3 PHARMACOLOGY & PHARMACY

Pharmacoepidemiology and Drug Safety Pub Date : 2026-09-01 DOI:10.1002/pds.70443

Mette Reilev, Lotte Rasmussen, Jonas Kanstrup Olsen, Martin Thomsen Ernst, Saad Hanif Abbasi, Rikke Wesselhoeft, Mette Bliddal, Jesper Hallas, Henrik Støvring

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引用次数: 0

Abstract

Background: In pharmacoepidemiologic research, correct assignment of the length of single dispensation is critical to build treatment episodes. The parametric reverse waiting time distribution (rWTD) is a particularly attractive data-driven method to estimate dispensation lengths.

Aim: To provide an easily accessible resource of estimated dispensation lengths covering all commonly used drugs for use in treatment episode building in applied pharmacoepidemiologic research.

Methods: We used a random 20% sample of the Danish population alive after 1st January 2000 and identified all their prescriptions filled between 2010 and 2022. We applied the rWTD with five random index dates for each individual to estimate parameters that allow calculation of dispensation length estimates. Parameters were estimated with and without age, sex, and dispensed amount as covariates.

Results: We present estimated dispensation lengths for the 20 most prescribed drugs and drug classes in Denmark. Estimated dispensation lengths for all drugs are provided online, and in a spreadsheet. The most prescribed drug was paracetamol with an estimated dispensation length of 194 days, while atorvastatin was the most commonly used drug indicated for long-term use with an estimated dispensation length of 165 days. The dispensation lengths for drugs varied according to age, dispensed volume, sex, and over time.

Conclusions: This is a comprehensive overview of dispensation lengths for all commonly prescribed drugs registered in the Danish National Prescription Registry. Data presented in an online resource can be utilized and modified by other researchers providing optimal conditions for high quality pharmacoepidemiologic research.

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建筑治疗阶段的配药长度目录-丹麦所有常用处方药的等待时间分布的应用。

背景：在药物流行病学研究中，正确分配单次用药时间对于建立治疗期至关重要。参数反向等待时间分布（rWTD）是一种特别有吸引力的数据驱动估计分配长度的方法。目的：为应用药物流行病学研究中治疗事件建立中常用药物的估计配药长度提供一个易于获取的资源。方法：我们随机抽取2000年1月1日之后存活的20%的丹麦人作为样本，并确定他们在2010年至2022年之间开具的所有处方。我们将rWTD应用于每个个体的五个随机索引日期，以估计允许计算分配长度估计的参数。参数估计有和没有年龄，性别和分配量作为协变量。结果：我们提出了估计的处方长度为20最常用的药物和药物类别在丹麦。所有药物的估计配药长度都在网上和电子表格中提供。处方最多的药物是扑热息痛，估计配药时间为194天，而阿托伐他汀是最常用的长期用药，估计配药时间为165天。药物的分配长度根据年龄、分配量、性别和时间而变化。结论：这是在丹麦国家处方注册处注册的所有常用处方药的配药长度的全面概述。在线资源中的数据可以被其他研究人员利用和修改，为高质量的药物流行病学研究提供最佳条件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmacoepidemiology and Drug Safety 医学-药学

CiteScore

4.80

自引率

7.70%

发文量

173

审稿时长

3 months

期刊介绍： The aim of Pharmacoepidemiology and Drug Safety is to provide an international forum for the communication and evaluation of data, methods and opinion in the discipline of pharmacoepidemiology. The Journal publishes peer-reviewed reports of original research, invited reviews and a variety of guest editorials and commentaries embracing scientific, medical, statistical, legal and economic aspects of pharmacoepidemiology and post-marketing surveillance of drug safety. Appropriate material in these categories may also be considered for publication as a Brief Report. Particular areas of interest include: design, analysis, results, and interpretation of studies looking at the benefit or safety of specific pharmaceuticals, biologics, or medical devices, including studies in pharmacovigilance, postmarketing surveillance, pharmacoeconomics, patient safety, molecular pharmacoepidemiology, or any other study within the broad field of pharmacoepidemiology; comparative effectiveness research relating to pharmaceuticals, biologics, and medical devices. Comparative effectiveness research is the generation and synthesis of evidence that compares the benefits and harms of alternative methods to prevent, diagnose, treat, and monitor a clinical condition, as these methods are truly used in the real world; methodologic contributions of relevance to pharmacoepidemiology, whether original contributions, reviews of existing methods, or tutorials for how to apply the methods of pharmacoepidemiology; assessments of harm versus benefit in drug therapy; patterns of drug utilization; relationships between pharmacoepidemiology and the formulation and interpretation of regulatory guidelines; evaluations of risk management plans and programmes relating to pharmaceuticals, biologics and medical devices.