CD10 - A Matrix Metallopeptidase Expression in Colorectal Carcinogenesis.

Abstract

Background: Colorectal cancer is the fourth leading cause of cancer-related mortality worldwide. It is more prevalent in developed countries but is increasingly affecting developing nations in Asia and Africa. CD10 is a cell surface zinc-dependent matrix metalloproteinase which may play a crucial role in tumour progression, invasion and metastasis.

Aims: The present study was done to analyse the CD10 role and its expression in colorectal Cancer.

Materials and methods: This cross-sectional study includes 58 cases, including colorectal adenomas (16) and carcinomas (58) over the period of 1½ years. The staining pattern and intensity of CD10 immunostaining were correlated with clinicopathological features of the cases.

Results: The maximum number of cases were over 50 years of age, and the most common site of tumour was the rectosigmoid region. Our study showed increasing expression of CD10 from adenomas to adenocarcinomas, suggesting its role in colorectal tumourigenesis. This study highlights a significant increase in CD10 expression in adenocarcinomas compared to adenomas, reinforcing its importance in malignant transformation.

Conclusion: The study concludes that there is a significant association between CD10 expression and colorectal carcinogenesis. CD10 may play a role in colorectal tumour progression and could be a potential target for anti-cancer therapy, particularly in rectosigmoid cancers.