{"title":"Histone deacetylase as a potential therapeutic target for memory dysfunction during aging and neurodegenerative disorders.","authors":"Padmanabh Singh, Mahendra Kumar Thakur","doi":"10.1016/bs.mie.2026.05.037","DOIUrl":null,"url":null,"abstract":"<p><p>Brain aging is a natural biological process characterized by gradual structural, molecular, and functional changes in the brain over time. Aging is the major risk factor for neurodegenerative diseases characterized by progressive neuronal loss, cognitive decline, and impaired motor function. In recent years, growing evidence has highlighted the importance of epigenetic regulation in the development and progression of these disorders. Among these epigenetic regulators, histone deacetylases (HDACs) have emerged as critical modulators of gene expression and neuronal function. Dysregulation of HDAC activity has been increasingly implicated in the pathogenesis of several neurodegenerative diseases. Abnormal HDAC expression or activity can alter transcription of genes involved in neuronal survival and synaptic integrity, which leads to neuronal dysfunction and degeneration. Pharmacological inhibition of HDAC activity has been shown to restore histone acetylation levels, enhance the expression of neuroprotective genes, and improve synaptic plasticity in various experimental models.</p>","PeriodicalId":18662,"journal":{"name":"Methods in enzymology","volume":"733 ","pages":"279-295"},"PeriodicalIF":0.0000,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Methods in enzymology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/bs.mie.2026.05.037","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/6/8 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
Brain aging is a natural biological process characterized by gradual structural, molecular, and functional changes in the brain over time. Aging is the major risk factor for neurodegenerative diseases characterized by progressive neuronal loss, cognitive decline, and impaired motor function. In recent years, growing evidence has highlighted the importance of epigenetic regulation in the development and progression of these disorders. Among these epigenetic regulators, histone deacetylases (HDACs) have emerged as critical modulators of gene expression and neuronal function. Dysregulation of HDAC activity has been increasingly implicated in the pathogenesis of several neurodegenerative diseases. Abnormal HDAC expression or activity can alter transcription of genes involved in neuronal survival and synaptic integrity, which leads to neuronal dysfunction and degeneration. Pharmacological inhibition of HDAC activity has been shown to restore histone acetylation levels, enhance the expression of neuroprotective genes, and improve synaptic plasticity in various experimental models.
期刊介绍：
The critically acclaimed laboratory standard for almost 50 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Each volume is eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 500 volumes the series contains much material still relevant today and is truly an essential publication for researchers in all fields of life sciences, including microbiology, biochemistry, cancer research and genetics-just to name a few. Five of the 2013 Nobel Laureates have edited or contributed to volumes of MIE.
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