Ahmet Bilgi, Osman Yıldırım, Rrezearta Cungu, Rabia Nur Sağlam, Şeyma Kılıç, Cetin Çelik, Mehmet Kulhan
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引用次数: 0
Abstract
Objectives: Postpartum depressive symptoms (PDSs) are a common psychiatric condition with multifactorial aetiology. Haematological inflammatory markers such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) have been proposed as indicators of systemic inflammation in mood disorders. This study aimed to investigate the association between these markers and PDSs in a homogeneous sample of first-time mothers.
Design: This was a cross-sectional observational study. Participants/Materials: Ninety-two primiparous women attending a routine 2-week postpartum follow-up were included. Inclusion criteria comprised age ≥18 years, singleton term pregnancy, and attendance at postpartum follow-up.
Setting: The review was conducted in a Department of Obstetrics and Gynaecology, Selçuk University Faculty of Medicine, Türkiye.
Methods: Depressive symptoms were assessed using the validated Turkish Edinburgh Postnatal Depression Scale (EPDS), with a cut-off score of ≥12. Complete blood count parameters were analysed, and NLR, PLR, and MLR were calculated. Statistical analyses included independent samples t-tests, Mann-Whitney U tests, chi-square tests, and binary logistic regression analysis.
Results: Maternal and neonatal characteristics were comparable between groups. NLR, PLR, and MLR values did not differ significantly between women with and without PDSs. Logistic regression analysis demonstrated that none of these markers were independent predictors of PDSs (all p > 0.05).
Limitations: The cross-sectional design precludes causal inference. Inflammatory markers were assessed at a single postpartum time point, and psychosocial factors potentially associated with depressive symptoms were not systematically evaluated.
Conclusions: In this study, NLR, PLR, and MLR were not associated with PDSs. These findings suggest that simple blood count-derived ratios may have limited utility as standalone indicators of PDSs.
期刊介绍：
This journal covers the most active and promising areas of current research in gynecology and obstetrics. Invited, well-referenced reviews by noted experts keep readers in touch with the general framework and direction of international study. Original papers report selected experimental and clinical investigations in all fields related to gynecology, obstetrics and reproduction. Short communications are published to allow immediate discussion of new data. The international and interdisciplinary character of this periodical provides an avenue to less accessible sources and to worldwide research for investigators and practitioners.
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