Multimodal Ultrasound and Multispectral Imaging Combined With Investigator Global Assessment for Quantitative Evaluation of Rosacea: A Feasibility Study

IF 1 4区医学 Q1 DERMATOLOGY

Dermatologic Therapy Pub Date : 2026-08-17 DOI:10.1155/dth/4153163

Tiantian Ren, Baoyun Zhang, Aixia Wang, Li Wu, Si Chen, Xiao Luo, Weibo Cheng

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引用次数: 0

Abstract

Background

Current assessment of rosacea relies on subjective visual scoring, which often fails to capture subtle changes predictive of treatment response or progression. Multimodal imaging may provide complementary quantitative structural, vascular, and biomechanical information to improve disease evaluation.

Objective

To evaluate the feasibility of multimodal ultrasound, including grayscale ultrasound (GSUS), shear wave elastography (SWE), and ultramicro angiography (UMA)—combined with multispectral skin imaging (MSI) and investigator global assessment (IGA) scores in detecting rosacea and monitoring treatment response.

Methods

Forty participants (20 rosacea and 20 healthy controls) were examined. IGA erythema and papule scores and all imaging parameters were obtained from identical facial sites before and after 4-week barrier-repair therapy. The epidermal thickness (ET), dermal thickness (DT), color pixel percentage (CPP), SWE elasticity values (E_mean, E_max, and E_min), and erythema indices (EAR and REI) were extracted from the images. Data between the two groups were compared using Student’s t-test for normally distributed variables, the Mann–Whitney U test for nonnormal variables, and the chi-square or Fisher’s exact test for categorical variables. Diagnostic performance was assessed by measuring the area under the curve of a receiver operator characteristic curve (ROC).

Results

Compared with healthy controls, patients with rosacea exhibited significant alterations in ultrasound parameters, including reduced ET and DT and increased CPP, alongside significant changes in erythema-related parameters on multispectral imaging. ROC analysis showed that ET and CPP may have potential value in distinguishing rosacea from healthy skin. Following treatment, ET and DT increased, while CPP and IGA scores decreased, whereas SWE parameters showed no significant change.

Conclusion

MMUS combined with MSI and IGA enables quantitative assessment of structural, vascular, and erythema-related changes in rosacea. This multimodal imaging clinical approach may serve as an adjunctive objective tool for the evaluation and monitoring of rosacea.

Trial Registration: Chinese Clinical Trial Registry (ChiCTR): ChiCTR2600128241

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多模态超声和多光谱成像联合研究者全局评估定量评价酒渣鼻的可行性研究

目前对酒渣鼻的评估依赖于主观的视觉评分，这往往不能捕捉到预测治疗反应或进展的细微变化。多模态成像可以提供互补的定量结构、血管和生物力学信息，以改善疾病评估。目的探讨多模态超声包括灰度超声（GSUS）、横波弹性成像（SWE）和超微血管造影（UMA）联合多光谱皮肤成像（MSI）和研究者整体评估（IGA）评分检测酒渣鼻和监测治疗反应的可行性。方法对40例酒渣鼻患者（20例）和健康对照（20例）进行调查。在4周屏障修复治疗前后获得相同面部部位的IGA红斑和丘疹评分及所有影像学参数。从图像中提取表皮厚度（ET）、真皮厚度（DT）、颜色像素百分比（CPP）、SWE弹性值（E_mean、E_max和E_min）和红斑指数（EAR和REI）。对于正态分布变量，使用Student 's t检验，对于非正态变量，使用Mann-Whitney U检验，对于分类变量，使用卡方检验或Fisher精确检验。通过测量受试者特征曲线（ROC）曲线下面积来评估诊断效果。结果与健康对照组相比，酒渣鼻患者超声参数发生显著变化，包括ET和DT降低，CPP升高，多光谱成像红斑相关参数也发生显著变化。ROC分析显示ET和CPP在区分酒渣鼻和健康皮肤方面可能有潜在的价值。治疗后，ET和DT升高，CPP和IGA评分降低，而SWE参数无显著变化。结论MMUS联合MSI和IGA可以定量评估酒渣鼻的结构、血管和红斑相关变化。这种多模态影像学临床方法可作为评价和监测酒渣鼻的辅助客观工具。试验注册：中国临床试验注册中心（ChiCTR）： ChiCTR2600128241

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来源期刊

Dermatologic Therapy 医学-皮肤病学

CiteScore

7.00

自引率

8.30%

发文量

711

审稿时长

3 months

期刊介绍： Dermatologic Therapy has been created to fill an important void in the dermatologic literature: the lack of a readily available source of up-to-date information on the treatment of specific cutaneous diseases and the practical application of specific treatment modalities. Each issue of the journal consists of a series of scholarly review articles written by leaders in dermatology in which they describe, in very specific terms, how they treat particular cutaneous diseases and how they use specific therapeutic agents. The information contained in each issue is so practical and detailed that the reader should be able to directly apply various treatment approaches to daily clinical situations. Because of the specific and practical nature of this publication, Dermatologic Therapy not only serves as a readily available resource for the day-to-day treatment of patients, but also as an evolving therapeutic textbook for the treatment of dermatologic diseases.