HIF-1α sets the activation tempo of inflammatory macrophages

IF 16 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2026-08-20 DOI:10.1016/j.molcel.2026.07.032

Marta Manco,Alessia Zotta,Massimiliano Mazzone

引用次数: 0

Abstract

Hypoxia-inducible factor 1a (HIF-1α) sustains cell survival and metabolic adaptations under low-oxygen conditions and supports metabolic reprogramming of pro-inflammatory macrophages. In this issue of Molecular Cell, Davanzo and colleagues1 uncover a HIF-1α-dependent biphasic regulatory program of macrophage activation in response to inflammatory cues and delineate its dynamic role in shaping antimicrobial defenses.

查看原文本刊更多论文

HIF-1α设定炎症性巨噬细胞的激活速度

缺氧诱导因子1a （HIF-1α）在低氧条件下维持细胞存活和代谢适应，并支持促炎巨噬细胞的代谢重编程。在这一期的《分子细胞》杂志上，Davanzo及其同事揭示了巨噬细胞对炎症信号的激活中hif -1α-依赖的双相调控程序，并描述了其在形成抗菌防御中的动态作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.