High spatial resolution dual-ended readout PET detector based on continuous resistive layer silicon photomultiplier.

IF 3.1 3区 医学 Q2 ENGINEERING, BIOMEDICAL
Jiahao Xie, Haibo Wang, Junwei Du
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引用次数: 0

Abstract

Objective.Continuous resistive layer position-sensitive silicon photomultiplier (CRL PS-SiPM) is a class of position-sensitive SiPMs developed for the readout of fine-pitch scintillator crystal arrays. This study aimed to evaluate the performance of dual-ended readout positron emission tomography (PET) detectors based on CRL PS-SiPMs and 0.5 mm pitch LYSO arrays.Approach.A dual-ended readout detector was constructed by coupling two CRL PS-SiPMs to both ends of a 10 × 10 array of polished LYSO elements, each measuring 0.44 × 0.44 × 20 mm3. Each CRL PS-SiPM had an active area of 6.24 × 6.24 mm2and was fabricated using 20µm microcells. Detector performance, including flood histogram quality, energy resolution, and coincidence timing resolution (CTR), was characterized at bias voltages ranging from 30.0 to 33.0 V in 0.5 V increments, and at 3°C, 14°C, and 24°C. Depth-of-interaction (DOI) resolution was evaluated at the optimal bias voltage determined from the flood histogram and at all three temperatures.Main results.Temperature had a negligible effect on detector performance, indicating that CRL PS-SiPMs are practical photodetector candidates for high spatial resolution PET scanners. All LYSO crystals were clearly resolved in the flood histograms. At 24°C and a bias voltage of 32.5 V, which provided the best flood histogram, the average energy resolution, CTR, and DOI resolution across all crystals were 22.7 ± 3.4%, 1152 ± 43 ps, and 1.78 ± 0.20 mm, respectively.Significance.These results demonstrate that CRL PS-SiPMs are promising photodetectors for high spatial resolution PET applications, particularly for systems requiring detectors with sub-millimeter pitch scintillator crystal arrays and DOI capability.

基于连续电阻层硅光电倍增管的高空间分辨率双端读出PET探测器。
目的:连续电阻层位置敏感硅光电倍增管(CRL PS-SiPM)是一类用于细间距闪烁晶体阵列读出的位置敏感硅光电倍增管。本研究旨在评估基于CRL PS-SiPMs和0.5 mm间距LYSO阵列的双端读出正电子发射断层扫描(PET)探测器的性能。方法:通过将两个CRL PS-SiPMs耦合到10 × 10的抛光LYSO元件阵列的两端,构建了一个双端读出检测器,每个LYSO元件的尺寸为0.44 × 0.44 × 20 mm³。每个CRL PS-SiPM的有效面积为6.24 × 6.24 mm²,采用20µm微孔制备。在0.5 V增量、3°C、14°C和24°C的偏置电压范围为30.0至33.0 V时,对检测器的性能进行了表征,包括洪水直方图质量、能量分辨率和符合时序分辨率。根据洪水直方图和所有三种温度确定的最佳偏置电压,评估了相互作用深度(DOI)分辨率。主要结果:温度对探测器性能的影响可以忽略不计,表明CRL ps - sipm是高空间分辨率PET扫描仪的实用光电探测器候选者。所有LYSO晶体在洪水直方图中被清晰地分解。在24°C和32.5 V的偏置电压下,所有晶体的平均能量分辨率、符合时序分辨率和DOI分辨率分别为22.7±3.4%、1152±43 ps和1.78±0.20 mm。意义:这些结果表明,CRL ps - sipm是高空间分辨率PET应用中很有前途的光电探测器,特别是对于需要具有亚毫米间距闪烁体晶体阵列和DOI能力的探测器的系统。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Physics in medicine and biology
Physics in medicine and biology 医学-工程:生物医学
CiteScore
6.50
自引率
14.30%
发文量
409
审稿时长
2 months
期刊介绍: The development and application of theoretical, computational and experimental physics to medicine, physiology and biology. Topics covered are: therapy physics (including ionizing and non-ionizing radiation); biomedical imaging (e.g. x-ray, magnetic resonance, ultrasound, optical and nuclear imaging); image-guided interventions; image reconstruction and analysis (including kinetic modelling); artificial intelligence in biomedical physics and analysis; nanoparticles in imaging and therapy; radiobiology; radiation protection and patient dose monitoring; radiation dosimetry
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