Porcine circovirus 2 vaccination timing was not associated with piglets' serological response.

IF 0.9 3区农林科学 Q2 VETERINARY SCIENCES

Veterinary Record Pub Date : 2026-08-16 DOI:10.1002/vetr.70974

Lea Uotinen, Sanna Nikunen, Gitte Blach Nielsen, Mari Heinonen

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引用次数: 0

Abstract

Background: The development of immunity in pigs starts in utero, but piglets are born immunologically immature and rely on maternal antibodies. Weaning exposes piglets to multiple stressors, yet vaccination is commonly performed around weaning. This study evaluated whether the timing of intradermal porcine circovirus 2 (PCV2) vaccination in relation to weaning influences serological responses.

Methods: In substudy A, 84 piglets were vaccinated at 3.5 weeks; half were weaned the following day and half 1 week later. In substudy B, 84 piglets were vaccinated at 4.5 weeks; half were weaned 1 week before vaccination and half the following day. Blood samples were collected at vaccination and 4 weeks later. Serological responses were assessed using an AlphaLISA immunological assay and compared using Welch's two-sample t-tests.

Results: No significant differences in antibody titres were observed between weaning groups at any time point.

Limitations: This study assessed only serology after vaccination, and no cellular immune responses were analysed.

Conclusion: Vaccination timing in relation to weaning did not alter piglets' serological response.

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猪圆环病毒2型疫苗接种时间与仔猪血清学反应无关。

背景：猪的免疫发育始于子宫，但仔猪出生时免疫发育不成熟，依赖于母体抗体。断奶使仔猪暴露于多种应激源，但通常在断奶前后进行疫苗接种。本研究评估了断奶时皮内接种猪圆环病毒2 （PCV2）疫苗的时机是否会影响血清学反应。方法：在亚研究A中，84头仔猪在3.5周接种；一半在第二天断奶，一半在一周后断奶。在亚研究B中，84头仔猪在4.5周时接种疫苗；一半在接种前1周断奶，另一半在接种后1周断奶。接种疫苗时和4周后采集血样。采用AlphaLISA免疫试验评估血清学反应，并采用Welch双样本t检验进行比较。结果：断奶组间各时间点抗体滴度均无显著差异。局限性：本研究仅评估了疫苗接种后的血清学，未分析细胞免疫反应。结论：与断奶有关的疫苗接种时间没有改变仔猪的血清学反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Veterinary Record 农林科学-兽医学

CiteScore

2.10

自引率

9.10%

发文量

1181

审稿时长

6-12 weeks

期刊介绍： Veterinary Record (branded as Vet Record) is the official journal of the British Veterinary Association (BVA) and has been published weekly since 1888. It contains news, opinion, letters, scientific reviews and original research papers and communications on a wide range of veterinary topics, along with disease surveillance reports, obituaries, careers information, business and innovation news and summaries of research papers in other journals. It is published on behalf of the BVA by BMJ Group.