ATP1A1 variants spring a leak.

IF 3.2 2区医学 Q1 PHYSIOLOGY

Journal of General Physiology Pub Date : 2026-09-07 Epub Date: 2026-08-11 DOI:10.1085/jgp.202614091

Ben Short

引用次数: 0

Abstract

JGP study (Colmano et al. https://doi.org/10.1085/jgp.202513959) identifies passive leak currents as a likely common mechanism underlying hypomagnesemia with treatment-resistant seizures in patients with certain mutations in the Na+, K+-ATPase α1 subunit.

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ATP1A1变异会导致泄漏。

JGP研究（Colmano等https://doi.org/10.1085/jgp.202513959）发现，在Na+， K+- atp酶α1亚基发生某些突变的患者中，被动漏电流可能是低镁血症与治疗抵抗性癫痫的共同机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of General Physiology 医学-生理学

CiteScore

6.00

自引率

10.50%

发文量

审稿时长

6-12 weeks

期刊介绍： General physiology is the study of biological mechanisms through analytical investigations, which decipher the molecular and cellular mechanisms underlying biological function at all levels of organization. The mission of Journal of General Physiology (JGP) is to publish mechanistic and quantitative molecular and cellular physiology of the highest quality, to provide a best-in-class author experience, and to nurture future generations of independent researchers. The major emphasis is on physiological problems at the cellular and molecular level.