Vessel fractional flow reserve (vFFR) vs. optical coherence tomography in chronic coronary syndromes (VISION-FFR).

IF 3.4 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Clinical Research in Cardiology Pub Date : 2026-08-10 DOI:10.1007/s00392-026-02991-7

Piotr Baruś, Adrian Bednarek, Karol Sadowski, Karol Artur Sadowski, Łukasz Kołtowski, Adam Rdzanek, Arkadiusz Pietrasik, Grzegorz Opolski, Marcin Grabowski, Janusz Kochman, Mariusz Tomaniak

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引用次数: 0

Abstract

Background: Fractional flow reserve (FFR) is the gold standard for evaluating the functional significance of coronary stenosis. With advances in methods based on computational fluid dynamics and three-dimensional vessel reconstructions, non-invasive assessment using indices such as vessel FFR (vFFR) has become feasible.

Objectives: To evaluate the association between vFFR and optical coherence tomography (OCT)-derived parameters in patients with chronic coronary syndromes (CCS).

Methods: In this single-center, prospective, observational study, patients with CCS and intermediate coronary stenoses (40-80% lesions in coronary angiography), undergoing FFR, vFFR, and OCT assessments were enrolled. FFR and vFFR ≤ 0.8 was considered hemodynamically significant.

Results: A total of 106 patients with 120 lesions were enrolled. Sixty-two patients had vFFR ≤ 0.8, and 44 patients presented with vFFR > 0.8. The median vFFR in the vFFR-positive group was 0.72 (0.70-0.77) and in the vFFR-negative group 0.88 (0.85-0.92), p < 0.001. The sensitivity of vFFR for identifying FFR-positive lesions was 88.5% with 92.5% specificity, the area under curve was 0.905. On OCT analysis lesions with vFFR ≤ 0.8 had smaller minimal lumen area (MLA) (1.83 ± 0.92 mm² vs. 2.53 ± 1.33 mm², p = 0.001) and were longer (16.38 ± 9.66 mm vs. 10.79 ± 6.41 mm, p < 0.001). Multivariate analysis adjusted for gender, age, and left anterior descending artery location revealed that lower vFFR value was an independent predictor of smaller MLA (Exp(B) for logMLA = 0.92, p < 0.001).

Conclusions: vFFR cutoff value of 0.8 presents high accuracy associated with longer and more severe stenosis assessed by OCT in patients with chronic coronary syndromes.

Trial registration: ClinicalTrials.gov ID: NCT06844942.

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血管分数血流储备（vFFR）与慢性冠状动脉综合征的光学相干断层扫描（VISION-FFR）。

背景：血流储备分数（FFR）是评价冠状动脉狭窄功能意义的金标准。随着基于计算流体力学和三维血管重建方法的进步，利用血管FFR （vFFR）等指标进行无创评估已成为可能。目的：评价慢性冠状动脉综合征（CCS）患者vFFR与光学相干断层扫描（OCT）衍生参数之间的关系。方法：在这项单中心、前瞻性、观察性研究中，纳入了接受FFR、vFFR和OCT评估的CCS和中度冠状动脉狭窄（冠状动脉造影病变40-80%）患者。FFR和vFFR≤0.8为血流动力学显著。结果：共纳入106例患者，120个病变。vFFR≤0.8的患者有62例，vFFR > 0.8的患者有44例。vFFR阳性组的中位vFFR为0.72 (0.70-0.77)，vFFR阴性组的中位vFFR为0.88 (0.85-0.92)(p = 0.001)， vFFR较长（16.38±9.66 mm比10.79±6.41 mm, p）。结论：vFFR截断值为0.8与慢性冠脉综合征患者OCT评估的更长、更严重的狭窄相关，准确度较高。试验注册：ClinicalTrials.gov ID: NCT06844942。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Research in Cardiology 医学-心血管系统

CiteScore

11.40

自引率

4.00%

发文量

140

审稿时长

4-8 weeks

期刊介绍： Clinical Research in Cardiology is an international journal for clinical cardiovascular research. It provides a forum for original and review articles as well as critical perspective articles. Articles are only accepted if they meet stringent scientific standards and have undergone peer review. The journal regularly receives articles from the field of clinical cardiology, angiology, as well as heart and vascular surgery. As the official journal of the German Cardiac Society, it gives a current and competent survey on the diagnosis and therapy of heart and vascular diseases.