Jinkang He, Chenjie Liu, Jiayi Li, Lingjun Li, Hongyang Li
{"title":"Current insights into the metabolic dysregulation of keratinocytes in psoriasis: A review.","authors":"Jinkang He, Chenjie Liu, Jiayi Li, Lingjun Li, Hongyang Li","doi":"10.1016/j.jdermsci.2026.07.002","DOIUrl":null,"url":null,"abstract":"<p><p>Psoriasis is an inflammatory skin disease, which is distinguished by parakeratosis and hyperkeratosis. Abnormal keratinocyte activity is crucial to its onset and development. Recent evidence reveals the significance of metabolic reprogramming in keratinocytes during psoriasis progress, demonstrating its strong association with the control of immune and inflammatory responses in the cutaneous microenvironment. This review systematically outlines metabolic abnormalities in keratinocytes, emphasizing key metabolic targets in glucose, lipid, and amino acid metabolism that mediate psoriasis progression and discusses the application prospects of metabolic targets in clinical practice. The objective is to provide a rationale for developing novel psoriasis therapies based on the metabolic regulation of keratinocytes.</p>","PeriodicalId":94076,"journal":{"name":"Journal of dermatological science","volume":" ","pages":""},"PeriodicalIF":4.6000,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of dermatological science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.jdermsci.2026.07.002","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Psoriasis is an inflammatory skin disease, which is distinguished by parakeratosis and hyperkeratosis. Abnormal keratinocyte activity is crucial to its onset and development. Recent evidence reveals the significance of metabolic reprogramming in keratinocytes during psoriasis progress, demonstrating its strong association with the control of immune and inflammatory responses in the cutaneous microenvironment. This review systematically outlines metabolic abnormalities in keratinocytes, emphasizing key metabolic targets in glucose, lipid, and amino acid metabolism that mediate psoriasis progression and discusses the application prospects of metabolic targets in clinical practice. The objective is to provide a rationale for developing novel psoriasis therapies based on the metabolic regulation of keratinocytes.
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