In Vitro Formulation and Potential Biological Activities of Metabolites Consortium with High Biocompatibility Derived from Poly Herbal Plant Extracts

IF 1.1 4区综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES

National Academy Science Letters Pub Date : 2025-05-05 DOI:10.1007/s40009-025-01656-9

T. Abiraamavalli, S. Karthick Raja Namasivayam

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Abstract

In the present study, the metabolites consortium was formulated from solvent extract of Acorus calamus Tinospora cordifolia, Coscinium fenestratum, Terminalia chebula, Smilax china using green science principles followed by screening of biological activities like anti-oxidant, anti-inflammatory, anti-diabetic and anti-microbial activities. The metabolite consortium exhibited notable antioxidant activity, demonstrated by its significant free radical scavenging activity. Furthermore, the consortium did not induce adverse effects on human red blood cell membrane stabilization, indicating its anti-inflammatory properties, which were further supported by in silico analysis. Moreover, the metabolite consortium showed antibacterial activity by inhibiting the growth of bacterial strains. Its antidiabetic activity was confirmed through distinct changes in alpha-amylase enzyme activity upon treatment. These findings suggest the potential utilization of the metabolite consortium as an effective, safe, and biocompatible bioactive drug formulation.

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多聚植物提取物高生物相容性代谢物联合体的体外配方及潜在生物活性研究

本研究采用绿色科学的方法，对菖蒲（Acorus calamus, Tinospora cordifolia, coscium fenestratum, Terminalia chebula, Smilax china）的溶剂提取物进行了抗氧化、抗炎、抗糖尿病、抗微生物等生物活性的筛选。代谢物联合体具有显著的抗氧化活性，表现为其明显的自由基清除活性。此外，该化合物不会对人红细胞膜稳定性产生不良影响，表明其具有抗炎特性，硅分析进一步支持了这一点。此外，代谢物联合体通过抑制菌株的生长表现出抗菌活性。其抗糖尿病活性通过治疗后α -淀粉酶活性的明显变化得到证实。这些发现表明，代谢物联合体作为一种有效、安全、具有生物相容性的生物活性药物制剂具有潜在的应用价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

National Academy Science Letters 综合性期刊-综合性期刊

CiteScore

2.20

自引率

0.00%

发文量

审稿时长

12 months

期刊介绍： The National Academy Science Letters is published by the National Academy of Sciences, India, since 1978. The publication of this unique journal was started with a view to give quick and wide publicity to the innovations in all fields of science