Ginger Supplementation and Blood Pressure in Adults: A GRADE-Based Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials

IF 2.3 3区医学 Q3 NUTRITION & DIETETICS

Journal of Human Nutrition and Dietetics Pub Date : 2026-08-07 DOI:10.1111/jhn.70329

Mehdi Karimi, Omid Asbaghi, Hossein Rafiei, Kimia Kazemi, Sara Yazdizadeh, Ghazal Radman, Reza Hosseini, Mohammad Hossein Hosseini, Mahtab Sabet, Mohammad Ali Goudarzi

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引用次数: 0

Abstract

Background and Aim

Ginger (Zingiber officinale L.) contains bioactive compounds with vasodilatory properties that may benefit blood pressure (BP) regulation. However, findings from studies remain inconsistent. This systematic review and meta-analysis aimed to evaluate the effect of ginger supplementation on BP in adults.

Methods

The literature was systematically searched in PubMed, Web of Science, and Scopus from database inception through May 1, 2026, to identify eligible randomized controlled trials (RCTs) evaluating systolic and diastolic blood pressure (SBP, DBP). Pooled effect estimates were calculated as weighted mean differences (WMDs) using a random-effects model. Subgroup and sensitivity analyses, publication bias assessments, and both linear and nonlinear dose–response analyses were conducted. The risk of bias was evaluated using the RoB 2 tool, and the certainty of the evidence was assessed according to the GRADE framework.

Results

Twelve unique RCTs contributed 13 effect sizes for SBP and 12 effect sizes for DBP. Ginger supplementation significantly reduced SBP (WMD: –5.03 mmHg, 95% CI: –8.49, –1.57; p = 0.004) and DBP (WMD: –2.03 mmHg, 95% CI: –3.90, –0.15; p = 0.034). Subgroup-specific reductions were observed in trials enrolling participants with elevated baseline BP, using doses ≥ 2000 mg/day, including both sexes, and enrolling participants with obesity. Nonlinear dose–response analyses confirmed a significant inverse association between ginger dose and BP, whereas intervention duration had no meaningful influence. Findings remained robust in sensitivity analyses, and no evidence of publication bias was detected. GRADE assessment rated the certainty of the evidence as low, downgraded only for inconsistency.

Conclusion

Ginger supplementation was associated with modest reductions in BP, with potentially greater effects in higher-risk populations and at doses ≥ 2000 mg/day. However, substantial heterogeneity, short trial durations, and limited robustness of the DBP findings reduce confidence in these estimates. Further high-quality, long-term RCTs are needed before definitive clinical or dosing recommendations can be made.

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生姜补充剂对成人血压的影响：基于分级的系统评价和随机对照试验的剂量反应荟萃分析。

背景和目的：生姜（Zingiber officinale L.）含有具有血管舒张特性的生物活性化合物，可能有利于调节血压。然而，研究结果仍然不一致。本系统综述和荟萃分析旨在评估生姜补充剂对成人血压的影响。方法：系统检索PubMed、Web of Science和Scopus从数据库建立到2026年5月1日的文献，以确定符合条件的评估收缩压和舒张压（SBP， DBP）的随机对照试验（rct）。使用随机效应模型计算加权平均差（wmd）的合并效应估计。进行了亚组分析和敏感性分析、发表偏倚评估以及线性和非线性剂量-反应分析。使用RoB 2工具评估偏倚风险，并根据GRADE框架评估证据的确定性。结果：12个独特的随机对照试验对收缩压和舒张压分别产生了13个效应量和12个效应量。补充生姜可显著降低收缩压（WMD: -5.03 mmHg, 95% CI: -8.49, -1.57; p = 0.004）和舒张压（WMD: -2.03 mmHg, 95% CI: -3.90, -0.15; p = 0.034）。在纳入基线血压升高受试者的试验中，使用≥2000mg /天的剂量，包括男女，以及纳入肥胖受试者，观察到亚组特异性降低。非线性剂量-反应分析证实生姜剂量与血压呈显著负相关，而干预时间对血压无显著影响。结果在敏感性分析中仍然稳健，没有发现发表偏倚的证据。GRADE评估将证据的确定性评为低，仅因不一致而降级。结论：补充生姜与适度降低血压有关，在高危人群中，剂量≥2000mg /天的效果可能更大。然而，大量的异质性、较短的试验时间和DBP结果的有限稳健性降低了这些估计的可信度。在提出明确的临床或剂量建议之前，需要进一步进行高质量的长期随机对照试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Human Nutrition and Dietetics 医学-营养学

CiteScore

5.30

自引率

15.20%

发文量

133

审稿时长

6-12 weeks

期刊介绍： Journal of Human Nutrition and Dietetics is an international peer-reviewed journal publishing papers in applied nutrition and dietetics. Papers are therefore welcomed on: - Clinical nutrition and the practice of therapeutic dietetics - Clinical and professional guidelines - Public health nutrition and nutritional epidemiology - Dietary surveys and dietary assessment methodology - Health promotion and intervention studies and their effectiveness - Obesity, weight control and body composition - Research on psychological determinants of healthy and unhealthy eating behaviour. Focus can for example be on attitudes, brain correlates of food reward processing, social influences, impulsivity, cognitive control, cognitive processes, dieting, psychological treatments. - Appetite, Food intake and nutritional status - Nutrigenomics and molecular nutrition - The journal does not publish animal research The journal is published in an online-only format. No printed issue of this title will be produced but authors will still be able to order offprints of their own articles.