Palmitoylation modulates neutrophil anti-tumour function in liver metastasis

IF 27.5 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2026-08-05 DOI:10.1038/s42255-026-01581-1

Liang Zhou, Jun Cui

引用次数: 0

Abstract

How liver metastases evade immunity remains unclear. A new study published in Nature Metabolism reveals that DHHC17-driven laminin 511 palmitoylation and its subsequent secretion blunts neutrophil-mediated killing of metastatic cancer cells, uncovering a druggable immune checkpoint in the liver.

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棕榈酰化调节中性粒细胞在肝转移中的抗肿瘤功能。

肝转移如何逃避免疫尚不清楚。发表在《自然-代谢》杂志上的一项新研究表明，dhhc17驱动的层粘连蛋白511棕榈酰化及其随后的分泌减弱了中性粒细胞介导的转移性癌细胞的杀伤，揭示了肝脏中可药物免疫检查点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.