Study on the correlation between IDH gene mutation status in gliomas and metabolic parameters in 18F-FDG PET/CT.

IF 1.4 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Nuclear Medicine Communications Pub Date : 2026-08-04 DOI:10.1097/MNM.0000000000002215

Lei Zeng, Ling Jiang, Tieying Ning, Yuanyuan Zhao, Yongyi Zhang, Junchen Zhang

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引用次数: 0

Abstract

Aim: To explore the correlation between isocitrate dehydrogenase (IDH) mutation status and 18F-deoxyglucose (18F-FDG) PET/computed tomography (CT) metabolic parameters in gliomas, and screen imaging biomarkers for preoperative prediction of IDH genotype.

Methods: Clinical and preoperative PET/CT data of 85 pathologically confirmed glioma patients were retrospectively analyzed, including 34 IDH-mutant and 51 IDH-wild-type cases. Lesion maximum standard uptake value (SUVmax), SUVmax T/C (lesion-to-contralateral cortex) and SUVmax T/W (lesion-to-contralateral white matter) were measured. Intergroup differences were compared via one-way analysis of variance, and receiver operating characteristic curves were applied to assess the predictive efficacy of significant parameters.

Results: All three metabolic indices were markedly elevated in IDH-wild-type tumors: SUVmax (11.77 ± 5.94 vs. 9.46 ± 3.30; P = 0.042), SUVmax T/C (1.63 ± 0.67 vs. 1.34 ± 0.40; P = 0.028), SUVmax T/W (2.80 ± 1.19 vs. 2.31 ± 0.63; P = 0.024). SUVmax T/C [area under the curve (AUC) = 0.671] and SUVmax T/W (AUC = 0.668) showed moderate predictive value, whereas SUVmax had poor performance (AUC = 0.339). Patients with IDH mutation were significantly younger.

Conclusion: IDH-wild-type gliomas present stronger glycolytic metabolism. 18F-FDG PET/CT-derived SUVmax, SUVmax T/C, and SUVmax T/W allow noninvasive preoperative evaluation of IDH status, with normalized ratio parameters demonstrating better diagnostic stability. Higher metabolic heterogeneity exists in IDH-wild-type gliomas.

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胶质瘤中IDH基因突变状态与18F-FDG PET/CT代谢参数的相关性研究

目的：探讨异柠檬酸脱氢酶（IDH）突变状态与胶质瘤中18f -脱氧葡萄糖（18F-FDG） PET/ CT代谢参数的相关性，以及筛查成像生物标志物用于术前预测IDH基因型。方法：回顾性分析85例经病理证实的胶质瘤患者的临床及术前PET/CT资料，其中idh突变型34例，idh野生型51例。测量病变最大标准摄取值（SUVmax）、SUVmax T/C（病变对对侧皮质）和SUVmax T/W（病变对对侧白质）。采用单因素方差分析比较组间差异，采用受试者工作特征曲线评估显著参数的预测效果。结果：3项代谢指标：SUVmax（11.77±5.94比9.46±3.30,P = 0.042）、SUVmax T/C（1.63±0.67比1.34±0.40,P = 0.028）、SUVmax T/W（2.80±1.19比2.31±0.63,P = 0.024）在idh野生型肿瘤中均显著升高。SUVmax T/C[曲线下面积(AUC) = 0.671]和SUVmax T/W （AUC = 0.668）具有中等预测价值，而SUVmax表现较差（AUC = 0.339）。IDH突变患者明显年轻化。结论：idh野生型胶质瘤具有较强的糖酵解代谢。18F-FDG PET/ ct衍生的SUVmax、SUVmax T/C和SUVmax T/W可用于IDH状态的无创术前评估，其归一化比率参数具有更好的诊断稳定性。idh野生型胶质瘤存在较高的代谢异质性。

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来源期刊

Nuclear Medicine Communications 医学-核医学

CiteScore

2.20

自引率

6.70%

发文量

212

审稿时长

3-8 weeks

期刊介绍： Nuclear Medicine Communications, the official journal of the British Nuclear Medicine Society, is a rapid communications journal covering nuclear medicine and molecular imaging with radionuclides, and the basic supporting sciences. As well as clinical research and commentary, manuscripts describing research on preclinical and basic sciences (radiochemistry, radiopharmacy, radiobiology, radiopharmacology, medical physics, computing and engineering, and technical and nursing professions involved in delivering nuclear medicine services) are welcomed, as the journal is intended to be of interest internationally to all members of the many medical and non-medical disciplines involved in nuclear medicine. In addition to papers reporting original studies, frankly written editorials and topical reviews are a regular feature of the journal.