Mechanistic Study on the Species Differences in Metabolism and Excretion Pathways of Ivarmacitinib (SHR0302) between Humans and Rats

IF 3.6 3区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Metabolism and Disposition Pub Date : 2026-07-01 DOI:10.1016/j.dmd.2026.100373

Xintong Huang, Dongyu Zhuang, Yuandong Zheng, Dafang Zhong, Xingxing Diao

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伊瓦马替尼（SHR0302）在人与大鼠代谢和排泄途径的物种差异机制研究

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Metabolism and Disposition 医学-药学

CiteScore

6.50

自引率

12.80%

发文量

128

审稿时长

3 months

期刊介绍： An important reference for all pharmacology and toxicology departments, DMD is also a valuable resource for medicinal chemists involved in drug design and biochemists with an interest in drug metabolism, expression of drug metabolizing enzymes, and regulation of drug metabolizing enzyme gene expression. Articles provide experimental results from in vitro and in vivo systems that bring you significant and original information on metabolism and disposition of endogenous and exogenous compounds, including pharmacologic agents and environmental chemicals.

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collagen I