Identification of Gln422 in transmembrane domain 9 as a key amino acid residue for the selective transport of ginsenoside Re by OATP1B3

IF 3.6 3区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Metabolism and Disposition Pub Date : 2026-07-01 DOI:10.1016/j.dmd.2026.100379

Han Liu, S Chen, Chen Zhang, Yao Dong, Lu Yang, Jiayu Jiang, Ru Huan, Chunshan Gui

引用次数: 0

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跨膜结构域9中Gln422作为OATP1B3选择性转运人参皂苷Re的关键氨基酸残基的鉴定

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Metabolism and Disposition 医学-药学

CiteScore

6.50

自引率

12.80%

发文量

128

审稿时长

3 months

期刊介绍： An important reference for all pharmacology and toxicology departments, DMD is also a valuable resource for medicinal chemists involved in drug design and biochemists with an interest in drug metabolism, expression of drug metabolizing enzymes, and regulation of drug metabolizing enzyme gene expression. Articles provide experimental results from in vitro and in vivo systems that bring you significant and original information on metabolism and disposition of endogenous and exogenous compounds, including pharmacologic agents and environmental chemicals.