Phylogenetic and Mutational Analysis of the Tax Gene in the Human T-Lymphotropic Virus 1 (HTLV-1) in Three Provinces of Iran.

IF 1.6 4区医学 Q3 Medicine

Iranian Journal of Public Health Pub Date : 2025-12-01 DOI:10.18502/ijph.v54i12.20847

Bezhan Noori, Vahid Shahnavaz, Atefeh Bahavar, Zohreh Sharifi, Parnaz Kafialqora, Zahra Navi, Abbas Rahimi Foroushani, Mohammadreza Shafiei, Seyed Mohammad Jazayeri, Sayed-Hamidreza Mozhgani, Mehdi Norouzi

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引用次数: 0

Abstract

Background: Human T-lymphotropic virus type 1 (HTLV-1) is considered a health issue in Iran. However, its genetic diversity and molecular epidemiologic phylogeny remain poorly characterized.

Methods: The Tax gene of 9 asymptomatic individuals across Alborz, Gilan, and Ardabil provinces of Iran was sequenced and analyzed phylogenetically using MEGA-X.

Results: All strains clustered within the Cosmopolitan subtype a, showing high genetic similarity to Japanese and Chinese references. Positive selection (dN/dS > 1) was observed in all samples. Strikingly, the Alborz ISO32 strain exhibited 10 unique nonsynonymous mutations, suggesting regional evolutionary divergence.

Conclusion: This study, as the first multi-provincial study in Iran, reveals the essential requirement for systematic tracking of HTLV-1 genetic diversity and designing prevention programs tailored to each region.

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伊朗三省人类嗜t淋巴病毒1型（HTLV-1）中Tax基因的系统发育和突变分析

背景：人类嗜t淋巴病毒1型（HTLV-1）在伊朗被认为是一个健康问题。然而，其遗传多样性和分子流行病学系统发育特征尚不清楚。方法：利用MEGA-X对伊朗Alborz、Gilan和Ardabil省9例无症状个体的Tax基因进行测序和系统发育分析。结果：所有菌株均聚集在世界性a亚型内，与日本和中国的参考文献具有较高的遗传相似性。所有样品均呈阳性选择（dN/dS > 1）。引人注目的是，Alborz ISO32菌株表现出10个独特的非同义突变，表明区域进化差异。结论：本研究是伊朗首个跨省研究，揭示了系统跟踪HTLV-1遗传多样性和设计适合每个地区的预防方案的基本要求。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Iranian Journal of Public Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

2.20

自引率

7.10%

发文量

审稿时长

2 months

期刊介绍： Iranian Journal of Public Health has been continuously published since 1971, as the only Journal in all health domains, with wide distribution (including WHO in Geneva and Cairo) in two languages (English and Persian). From 2001 issue, the Journal is published only in English language. During the last 41 years more than 2000 scientific research papers, results of health activities, surveys and services, have been published in this Journal. To meet the increasing demand of respected researchers, as of January 2012, the Journal is published monthly. I wish this will assist to promote the level of global knowledge. The main topics that the Journal would welcome are: Bioethics, Disaster and Health, Entomology, Epidemiology, Health and Environment, Health Economics, Health Services, Immunology, Medical Genetics, Mental Health, Microbiology, Nutrition and Food Safety, Occupational Health, Oral Health. We would be very delighted to receive your Original papers, Review Articles, Short communications, Case reports and Scientific Letters to the Editor on the above mentioned research areas.