Radiomic analysis of pathologically confirmed mandibular osteoradionecrosis to identify cases with associated recurrence: a multicentric retrospective study

IF 3.2 Q2 ONCOLOGY

Physics and Imaging in Radiation Oncology Pub Date : 2026-07-01 Epub Date: 2026-07-03 DOI:10.1016/j.phro.2026.101031

Olivier Ozcan, Remy Laluc, Aline Carsin-Vue, Nathaniel Assouly, Esteban Brenet, Antonio Da Silva Ribeiro Mota, Stephane Derruau, Marine Fontaine, Camille Invernizzi, Oriane Marques, Nicolas Passat, Arnaud Beddok

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Abstract

Differentiating mandibular osteoradionecrosis (ORN) from tumor recurrence remains challenging on preoperative imaging. We conducted a multicenter retrospective study including 24 patients with histologically confirmed ORN who underwent surgery and had preoperative CT available. Radiomic features were extracted using an IBSI-compliant pipeline and compared between pure ORN (n = 21) and ORN with recurrence (n = 3). Three features showed nominal uncorrected differences between groups. Given the rarity of histologically confirmed recurrence, this study was designed as an exploratory hypothesis-generating analysis. These findings suggest that CT radiomics may capture subtle imaging differences and warrant validation in larger cohorts.

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病理证实的下颌骨放射性骨坏死的放射组学分析以确定相关复发病例：一项多中心回顾性研究

鉴别下颌骨放射性骨坏死（ORN）与肿瘤复发仍然具有挑战性的术前影像学。我们进行了一项多中心回顾性研究，包括24例组织学证实的ORN患者，他们接受了手术，术前有CT。使用符合ibsi的管道提取放射学特征，并将纯ORN （n = 21）与复发ORN （n = 3）进行比较。三个特征显示出各组之间名义上的未校正差异。鉴于组织学证实复发的罕见性，本研究被设计为一种探索性的假设生成分析。这些发现表明，CT放射组学可以捕捉到细微的成像差异，并在更大的队列中得到验证。

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