Novel perspective on immune cell regulation in gastrointestinal inflammation: the role of extracellular vesicles and therapeutic prospects.

IF 3.8 4区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Experimental Biology and Medicine Pub Date : 2026-07-17 eCollection Date: 2026-01-01 DOI:10.3389/ebm.2026.11114

Jianshu Wang, Junxuan Xu, Zilu Cui, Jing Wu

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Abstract

Gastrointestinal inflammation is an inflammatory disease arising from immune imbalance in any segment of the digestive tract, triggered by various factors. Immune cells play important roles in both the onset and resolution of gastrointestinal inflammation. With the recent extensive research on extracellular vesicles, the mechanism by which immune cells regulate gastrointestinal inflammation through extracellular vesicles has gradually gained recognition within the scientific community. Extracellular vesicles derived from immune cells can communicate with other immune cells in the digestive tract and directly regulate digestive tract epithelial cells. Furthermore, with advances in biological nanotechnology, immune cell-derived extracellular vesicles may be used to treat inflammatory gastrointestinal diseases. This review focuses on delineating the role of immune cell-derived extracellular vesicles in gastrointestinal inflammation and exploring their potential applications in treating these inflammatory diseases.

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免疫细胞调控胃肠道炎症的新视角：细胞外囊泡的作用和治疗前景。

胃肠道炎症是由多种因素引起的消化道任一部位免疫失衡所引起的炎症性疾病。免疫细胞在胃肠道炎症的发生和消退中都起着重要作用。随着近年来对细胞外囊泡的广泛研究，免疫细胞通过细胞外囊泡调节胃肠道炎症的机制逐渐得到科学界的认可。免疫细胞衍生的细胞外囊泡可以与消化道内的其他免疫细胞进行通讯，直接调节消化道上皮细胞。此外，随着生物纳米技术的进步，免疫细胞来源的细胞外囊泡可能用于治疗炎症性胃肠道疾病。本文综述了免疫细胞源性细胞外囊泡在胃肠道炎症中的作用，并探讨了其在治疗这些炎症性疾病中的潜在应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

6.00

自引率

0.00%

发文量

157

审稿时长

1 months

期刊介绍： Experimental Biology and Medicine (EBM) is a global, peer-reviewed journal dedicated to the publication of multidisciplinary and interdisciplinary research in the biomedical sciences. EBM provides both research and review articles as well as meeting symposia and brief communications. Articles in EBM represent cutting edge research at the overlapping junctions of the biological, physical and engineering sciences that impact upon the health and welfare of the world''s population. Topics covered in EBM include: Anatomy/Pathology; Biochemistry and Molecular Biology; Bioimaging; Biomedical Engineering; Bionanoscience; Cell and Developmental Biology; Endocrinology and Nutrition; Environmental Health/Biomarkers/Precision Medicine; Genomics, Proteomics, and Bioinformatics; Immunology/Microbiology/Virology; Mechanisms of Aging; Neuroscience; Pharmacology and Toxicology; Physiology; Stem Cell Biology; Structural Biology; Systems Biology and Microphysiological Systems; and Translational Research.