Notificación de sospechas de reacciones adversas a medicamentos por enfermeras a un programa de farmacovigilancia hospitalaria. Estudio descriptivo retrospectivo

IF 1.7 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Revista clinica espanola Pub Date : 2026-08-01 Epub Date: 2026-06-13 DOI:10.1016/j.rce.2026.502577

P. Ordóñez-Rufat, D. Rodríguez-Cumplido, R. Llop-Rius, A. Tarres-Martínez, P. Hereu-Boher

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Abstract

Introduction

Adverse drug reactions (ADR) are a common cause of illness. The Spontaneous reporting of adverse drug reactions is essential to characterize drug toxicity. Nurses, due to their proximity to patients, can contribute to detect them. The purpose is to describe the number of notifications of adverse drug reactions from nurses after a set of actions aimed at promoting reporting.

Material and method

Single-center observational, retrospective, and descriptive study on the characteristics and number of spontaneous ADR reports made by nurses following the implementation of informational/training actions in different healthcare areas of a tertiary hospital.

Results

Of the total 806 of suspected adverse drug reactions, nurses reported 124 (38.51%). There was a predominance of women 77 (62,1%), with a mean age of 54 years; 22.6% were over 65 years of age and 61.3% were polymedicated (five or more drugs prescribed). The most frequently reported reactions were skin disorders, and 71% of them resolved within 24 hours. Intravenous contrast agents for diagnostic testing were the most reported drugs. In 116 (93.5%) of cases, the reactions were considered definitively or probably related to the drug.

Conclusions

It is essential to promote the role of nurses in increasing adverse drug reactions reporting in order to sustainably strengthen pharmacovigilance systems.

Continuous training that is adapted and maintained over time, as well as intuitive and accessible notification circuits, can contribute to improving participation.

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护士向医院药物监测项目报告疑似药物不良反应。回顾描述性研究

药物不良反应（ADR）是疾病的常见原因。药物不良反应的自发报告是表征药物毒性的必要条件。护士，由于他们接近病人，可以帮助发现他们。目的是描述在一系列旨在促进报告的行动后，护士通报药物不良反应的数量。材料和方法对某三级医院不同医疗区域实施信息/培训行动后护士自发ADR报告的特征和数量进行单中心观察、回顾性和描述性研究。结果806例疑似药物不良反应中，护士报告124例（38.51%）；以女性77例（62.1%）为主，平均年龄54岁；22.6%的患者年龄超过65岁，61.3%的患者使用多种药物（处方5种或5种以上药物）。报告中最常见的反应是皮肤疾病，其中71%在24小时内消退。用于诊断测试的静脉造影剂是报告最多的药物。在116例（93.5%）病例中，这些反应被认为是明确的或可能与药物有关。结论提高护士在增加药物不良反应报告中的作用，是持续加强药物警戒体系的关键。随着时间的推移进行调整和维持的持续培训，以及直观和易于获取的通知电路，都有助于提高参与程度。

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来源期刊

Revista clinica espanola 医学-医学：内科

CiteScore

4.40

自引率

6.90%

发文量

审稿时长

28 days

期刊介绍： Revista Clínica Española published its first issue in 1940 and is the body of expression of the Spanish Society of Internal Medicine (SEMI). The journal fully endorses the goals of updating knowledge and facilitating the acquisition of key developments in internal medicine applied to clinical practice. Revista Clínica Española is subject to a thorough double blind review of the received articles written in Spanish or English. Nine issues are published each year, including mostly originals, reviews and consensus documents.