{"title":"Diagnostic potential of B-cell translocation gene 2 in IgA nephropathy: Insights from molecular mechanisms","authors":"Min Kou, Mo Dan, Juan Cheng, Sheng Ge, Ruimin Ren","doi":"10.1002/ccs3.70082","DOIUrl":null,"url":null,"abstract":"<p>IgA nephropathy (IgAN) is a prevalent glomerular disease characterized by IgA deposition, chronic inflammation, and fibrosis, leading to end-stage renal disease. This study explored B-cell translocation gene 2 (BTG2) as a biomarker and treatment target for IgAN progression. Through integrated expression datasets and functional analyses, BTG2 emerged as a key gene with downregulation in renal tissues of IgAN patients, showing high diagnostic accuracy. BTG2 influenced the immune microenvironment by modulating T follicular helper cells and M0 macrophages. Moreover, BTG2 overexpression mitigated IgA deposition and fibrosis, whereas its silencing exacerbated these pathological changes. The study highlights BTG2 as a promising diagnostic tool and therapeutic target, shedding light on potential treatment strategies for IgAN.</p>","PeriodicalId":15226,"journal":{"name":"Journal of Cell Communication and Signaling","volume":"20 3","pages":""},"PeriodicalIF":4.0000,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13384246/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cell Communication and Signaling","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ccs3.70082","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
IgA nephropathy (IgAN) is a prevalent glomerular disease characterized by IgA deposition, chronic inflammation, and fibrosis, leading to end-stage renal disease. This study explored B-cell translocation gene 2 (BTG2) as a biomarker and treatment target for IgAN progression. Through integrated expression datasets and functional analyses, BTG2 emerged as a key gene with downregulation in renal tissues of IgAN patients, showing high diagnostic accuracy. BTG2 influenced the immune microenvironment by modulating T follicular helper cells and M0 macrophages. Moreover, BTG2 overexpression mitigated IgA deposition and fibrosis, whereas its silencing exacerbated these pathological changes. The study highlights BTG2 as a promising diagnostic tool and therapeutic target, shedding light on potential treatment strategies for IgAN.
期刊介绍：
The Journal of Cell Communication and Signaling provides a forum for fundamental and translational research. In particular, it publishes papers discussing intercellular and intracellular signaling pathways that are particularly important to understand how cells interact with each other and with the surrounding environment, and how cellular behavior contributes to pathological states. JCCS encourages the submission of research manuscripts, timely reviews and short commentaries discussing recent publications, key developments and controversies.
Research manuscripts can be published under two different sections :
In the Pathology and Translational Research Section (Section Editor Andrew Leask) , manuscripts report original research dealing with celllular aspects of normal and pathological signaling and communication, with a particular interest in translational research.
In the Molecular Signaling Section (Section Editor Satoshi Kubota) manuscripts report original signaling research performed at molecular levels with a particular interest in the functions of intracellular and membrane components involved in cell signaling.
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