STING-mediated cancer immunotherapy: emerging modalities and beyond.

IF 24 1区医学 Q1 PHARMACOLOGY & PHARMACY

Trends in pharmacological sciences Pub Date : 2026-07-25 DOI:10.1016/j.tips.2026.07.002

Ramesha Hanumanthappa, Nandakumar Dalavaikodihalli Nanjaiah, Sudhir H Ranganath

引用次数: 0

Abstract

The clinical translation of stimulator of interferon genes (STING)agonist-based cancer immunotherapy is limited by uncontrolled and sustained STING activation, which leads to immune exhaustion and systemic toxicity. In this forum, we critically analyze recent advances, including stimuli-responsive, biomimetic, pulsatile, intracellular-triggered release, and synergistic systems that enable precise spatiotemporal STING activation, as well as associated gaps in clinical translation. Finally, we present futuristic perspectives on next-generation STING-based cancer immunotherapy strategies.

查看原文本刊更多论文

sting介导的癌症免疫治疗：新兴模式和超越。

基于干扰素基因刺激剂（STING）激动剂的癌症免疫治疗的临床翻译受到不受控制和持续的STING激活的限制，这会导致免疫衰竭和全身毒性。在本次论坛中，我们批判性地分析了最近的进展，包括刺激反应，仿生，脉动，细胞内触发释放，以及能够精确时空激活STING的协同系统，以及临床翻译中的相关空白。最后，我们提出了下一代基于sting的癌症免疫治疗策略的未来展望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Trends in pharmacological sciences 医学-药学

CiteScore

23.90

自引率

0.70%

发文量

132

审稿时长

6-12 weeks

期刊介绍： Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research. The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics. Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles. Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.