Regulatory role of autophagy in epidermal function

Abstract

Autophagy, a highly conserved cellular degradation process, is essential for maintaining cellular homeostasis and responding to stress. Recent studies have highlighted the importance of autophagy in regulating epidermal functions, including keratinocyte differentiation and proliferation, epidermal lipid synthesis, inflammation, and antioxidation. In the epidermis, autophagy facilitates the removal of damaged organelles and protein aggregates, ensuring proper keratinocyte maturation and stratum corneum formation. Dysregulation of autophagy has been linked to various dermatological conditions, such as psoriasis, atopic dermatitis, and skin aging. Furthermore, autophagy modulates the inflammatory response in the skin by regulating cytokine production and immune cell activity. This review summarizes evidence supporting the role of autophagy in epidermal function and emphasizes its potential as a therapeutic target. Additionally, approaches to enhance autophagy are discussed.